Fig. 5

Quercetin regulates signaling molecules involved in PCa cell survival and apoptosis. Antibody microarray was performed on quercetin (Qu.)-treated and untreated (UT) DU-145 and PC-3 cell lines. The heat map was generated from normalized intensity data using CIMminer tool (Genomics and Bioinformatics group, NIH). The heat map represents fold change in phosphorylation status of cell survival and pro-/anti-apoptotic molecules in quercetin-treated DU-145 and PC-3 cells. Each cell in the heat map shows ratio of phosphorylated (P) to non-phosphorylated (N) protein in treated vs untreated sample. Red indicates increase while green represents decrease in phosphorylation of signaling molecules, and intensity of color depends on degree of phosphorylation