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Fig. 1 | World Journal of Surgical Oncology

Fig. 1

From: Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways

Fig. 1

Quercetin reduces cell viability and induces apoptosis in PCa cells. Normal prostate epithelial cells PrEC and PCa cells (LNCaP, DU-145, PC-3) were treated with quercetin, and MTT assay was used to determine cell viability (a). The EC50 was calculated from the equation of the line of best fit. PCa cells were treated with 40 μM (EC50) of quercetin, and vehicle-treated controls were stained with FITC-conjugated Annexin V and 7-AAD. Data was acquired by FACS and analyzed using FlowJo software (b). Dot plot shows percent (%) of early apoptotic (lower right quadrate) and late apoptotic cells (right upper quadrate). Apoptosis induced by quercetin (shown in top bar diagram) as well as induced necrotic cells (bottom bar diagram) were measured by paired t test to show significance compared to controls

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