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Table 4 Univariate and multivariate analyses of factors associated with OS and DFS

From: Safety and efficacy of dehydrated ethanol soaking of the operative field in the treatment of spontaneous hepatocellular carcinoma rupture

Univariate analysis
  Overall survival Disease-free survival
Variable Hazard ratio (95% CI) P value Hazard ratio(95% CI) P value
Age (≤ 47.0 vs. > 47.0) 1.045 (0.494–2.210) 0.908 0.902 (0.442–1.840) 0.777
Gender (female vs. male) 1.618 (0.549–4.767) 0.382 1.076 (0.375–3.089) 0.892
HBsAg (negative vs. positive) 0.756 (0.281–2.029) 0.578 1.254 (0.481–3.268) 0.643
AFP, IU/mL (≤ 400 vs. > 400) 1.000 (0.181–4.645) 0.345 1.669 (0.443–6.289) 0.276
AST, IU/L (≤ 40 vs. > 40) 1.005 (0.996–1.014) 0.257 1.004 (0.997–1.011) 0.229
ALT, IU/L (≤ 40 vs. > 40) 1.004 (0.993–1.015) 0.453 1.001 (0.990–1.012) 0.864
Child-Pugh classification(A vs. B and C) 0.458 (0.062–3.402) 0.445 0.646 (0.152–2.732) 0.552
Tumor size, cm (≤ 10 vs.> 10) 1.062 (0.446–2.528) 0.892 0.690 (0.298–1.598) 0.386
Tumor number (single vs .multiple) 0.849 (0.318–2.267) 0.744 0.571 (0.218–1.493) 0.253
Liver cirrhosis(no vs. yes) 0.819 (0.326–2.059) 0.671 0.605 (0.267–1.370) 0.228
Organ invasion(no vs. yes) 1.158 (0.511–2.625) 0.726 0.912 (0.508–2.298) 0.841
Vascular invasion (no vs. yes) 1.339 (0.535–3.355) 0.533 1.074 (0.504–2.288) 0.854
Pre-operation TACE (no vs. yes) 1.228 (0.415–3.633) 0.711 0.722 (0.251–2.073) 0.544
Type of treatment (DAW vs.DW) 1.828 (0.877–3.810) 0.107 1.951 (1.030–3.693) 0.040
Multivariate analyses     
Type of treatment N.A. 0.206 N.A. 0.331
  1. Multivariate analysis and Cox proportional hazards regression model were used. Variables were adopted for their prognostic significance by univariate analysis (P < 0.05)
  2. CI confidence interval, N.A. not applicable