Table 4 Univariate and multivariate analyses of factors associated with OS and DFS
Univariate analysis | ||||
|---|---|---|---|---|
Overall survival | Disease-free survival | |||
Variable | Hazard ratio (95% CI) | P value | Hazard ratio(95% CI) | P value |
Age (≤ 47.0 vs. > 47.0) | 1.045 (0.494–2.210) | 0.908 | 0.902 (0.442–1.840) | 0.777 |
Gender (female vs. male) | 1.618 (0.549–4.767) | 0.382 | 1.076 (0.375–3.089) | 0.892 |
HBsAg (negative vs. positive) | 0.756 (0.281–2.029) | 0.578 | 1.254 (0.481–3.268) | 0.643 |
AFP, IU/mL (≤ 400 vs. > 400) | 1.000 (0.181–4.645) | 0.345 | 1.669 (0.443–6.289) | 0.276 |
AST, IU/L (≤ 40 vs. > 40) | 1.005 (0.996–1.014) | 0.257 | 1.004 (0.997–1.011) | 0.229 |
ALT, IU/L (≤ 40 vs. > 40) | 1.004 (0.993–1.015) | 0.453 | 1.001 (0.990–1.012) | 0.864 |
Child-Pugh classification(A vs. B and C) | 0.458 (0.062–3.402) | 0.445 | 0.646 (0.152–2.732) | 0.552 |
Tumor size, cm (≤ 10 vs.> 10) | 1.062 (0.446–2.528) | 0.892 | 0.690 (0.298–1.598) | 0.386 |
Tumor number (single vs .multiple) | 0.849 (0.318–2.267) | 0.744 | 0.571 (0.218–1.493) | 0.253 |
Liver cirrhosis(no vs. yes) | 0.819 (0.326–2.059) | 0.671 | 0.605 (0.267–1.370) | 0.228 |
Organ invasion(no vs. yes) | 1.158 (0.511–2.625) | 0.726 | 0.912 (0.508–2.298) | 0.841 |
Vascular invasion (no vs. yes) | 1.339 (0.535–3.355) | 0.533 | 1.074 (0.504–2.288) | 0.854 |
Pre-operation TACE (no vs. yes) | 1.228 (0.415–3.633) | 0.711 | 0.722 (0.251–2.073) | 0.544 |
Type of treatment (DAW vs.DW) | 1.828 (0.877–3.810) | 0.107 | 1.951 (1.030–3.693) | 0.040 |
Multivariate analyses | ||||
Type of treatment | N.A. | 0.206 | N.A. | 0.331 |