Table 4 Top 10 significant KEGG pathway annotations
Term | Genes | Count | P value |
|---|---|---|---|
Focal adhesion | CAV2, CAV1, TNC, COL3A1, ITGA11, PTEN, ITGB1, DOCK1, LAMB2, COL27A1, ITGAV, ILK, COL6A2, COL6A1, PDGFC, PDGFD, LAMB1, THBS1, THBS2, AKT3, FN1, PRKCA, COL4A2, COL4A1, ROCK2, MET, ITGA1, ITGA4, BAD, FLNC, COL5A2, COL5A1, FLNA, LAMA2, VEGFC, LAMA4, ITGA5, COL1A2, PDGFRA, PDGFRB, COL1A1, LAMC1, MYLK, PARVA | 44 | 1.21E−12 |
ECM-receptor interaction | TNC, COL3A1, ITGA11, ITGB1, LAMB2, CD44, ITGAV, COL27A1, COL6A2, COL6A1, THBS1, LAMB1, THBS2, FN1, COL4A2, COL4A1, HSPG2, ITGA1, ITGA4, COL5A2, COL5A1, LAMA2, LAMA4, ITGA5, COL1A2, COL1A1, LAMC1 | 27 | 8.63E−12 |
Proteoglycans in cancer | WNT5A, CAV2, CAV1, WNT5B, MRAS, LUM, TLR4, DCN, MMP2, ITGB1, TIMP3, HOXD10, TGFB1, WNT2, CD44, ITGAV, RRAS, THBS1, FGF2, GPC1, TWIST2, AKT3, FN1, PRKCA, ROCK2, MET, HSPG2, CD63, FLNC, FLNA, PLAUR, PLCE1, ITGA5, ARAF, PTCH1 | 35 | 7.76E−08 |
Pathways in cancer | ADCY3, PPARD, PTGS2, GNA11, PPARG, MITF, LPAR1, MMP2, PTEN, GLI3, TGFB1, EDNRA, WNT2, CDKN2A, FGF2, AKT3, PRKCA, AR, PTGER3, ROCK2, RUNX1T1, VEGFC, PDGFRA, PDGFRB, LAMC1, WNT5A, WNT5B, GNAI1, KITLG, GNG11, GNG12, BDKRB2, ITGB1, LAMB2, ITGAV, RUNX1, LAMB1, TRAF5, FN1, BMP4, IL6, COL4A2, COL4A1, EPAS1, MET, TGFBR2, BAD, LAMA2, LAMA4, ADCY9, RASSF1, ARAF, PTCH1 | 53 | 1.75E−07 |
Amoebiasis | PRKCA, COL4A2, IL6, RAB7B, COL4A1, GNA11, COL3A1, TLR4, COL5A2, TGFB1, COL5A1, LAMA2, LAMA4, LAMB2, COL27A1, COL1A2, HSPB1, COL1A1, LAMC1, LAMB1, FN1 | 21 | 7.93E−06 |
PI3K-Akt signaling pathway | TNC, COL3A1, ITGA11, KITLG, TLR4, GNG11, GNG12, LPAR1, PTEN, ITGB1, LAMB2, COL27A1, ITGAV, COL6A2, CREB3L1, COL6A1, PDGFC, ANGPT1, PDGFD, LAMB1, THBS1, FGF2, THBS2, AKT3, FN1, PRKCA, IL6, COL4A2, COL4A1, MET, ITGA1, ITGA4, BAD, COL5A2, COL5A1, LAMA2, VEGFC, LAMA4, ITGA5, COL1A2, PDGFRA, PDGFRB, COL1A1, LAMC1 | 44 | 1.06E−05 |
Dilated cardiomyopathy | ADCY3, ITGA11, ITGA1, LMNA, CACNB3, ITGA4, TPM2, TPM1, ITGB1, TPM4, TGFB1, ADCY9, ITGA5, ITGAV, SGCD, CACNA1C, SGCB | 17 | 5.69E−05 |
Hypertrophic cardiomyopathy (HCM) | IL6, ITGA1, LMNA, ITGA11, CACNB3, ITGA4, TPM2, TPM1, ITGB1, TPM4, TGFB1, ITGA5, ITGAV, SGCD, CACNA1C, SGCB | 16 | 8.62E−05 |
Protein digestion and absorption | COL4A2, SLC8A1, COL4A1, COL3A1, COL15A1, COL5A2, COL5A1, COL7A1, COL27A1, PRSS3, COL6A2, COL1A2, COL12A1, COL6A1, COL1A1, DPP4 | 16 | 3.50E−04 |
Axon guidance | PLXNA3, NRP1, PLXNA1, ROCK2, GNAI1, MET, NTN4, EPHB3, ITGB1, SLIT2, SLIT3, SEMA5A, CFL2, PPP3CB, SEMA3C, NFATC4, SEMA3B, RHOD, SRGAP1 | 19 | 9.54E−04 |