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Table 1 Cancers of the intrathoracic lymph nodes with unknown primary site

From: Lymph node cancer of the mediastinum with a putative necrotic primary lesion in the lung: a case report

Case

Author

Age (years)

Sex

Smoking history

Histology

Elevated TMs

Location

Treatment

Adjuvant treatment

Follow-up (months)

Outcome

1

Morita Y

56

Male

+

SQ

None

Med

LB and LND

None

20

Alive without recurrence

2

Kohdono S

67

Male

+

LA

None

Med

Tumor resection

RTx

6

Died of recurrence

3

Kohdono S

58

Female

+

LA

CEA

Med

LB and LND

RTx

6

Alive with recurrence

4

Kohdono S

56

Male

+

Small

SCC

rt. Hilum

LB and LND

None

16

Alive without recurrence

5

Blanco N

56

Male

+

SQ

no data

Med

Tumor resection

CRT

No data

Alive without recurrence

6

Kawasaki H

69

Male

No data

LA

CEA

rt. Hilum

LB and LND

None

20

Alive without recurrence

7

Tomita M

56

Male

+

SQ

SCC

lt. Hilum

Tumor resection

None

32

Alive without recurrence

8

Miwa K

72

Male

+

SQ

CEA

Med

LND

RTx

82

Alive without recurrence

9

Miwa K

78

Male

+

AD

CEA

Med

LND

RTx

44

Alive without recurrence

10

Miwa K

70

Male

+

SQ

None

Med

CRT

N/A

33

Alive without disease progression

11

Miwa K

76

Male

+

Undifferentiated

CEA

Med

CRT

N/A

24

Alive without disease progression

12

Shiota Y

69

Male

+

AD

CEA

Med

CRT

N/A

22

Alive without disease progression

13

Harada H

83

Female

No data

AD

NSE

Med

Tumor resection

None

38

Alive without recurrence

14

Watanabe N

55

Female

AD

CEA

Med

ALK-TKI

N/A

3

Alive without disease progression

15

Kim M.J.

59

Male

+

SQ

None

rt. Hilum

PN and LND

CRT

No data

Alive without recurrence

16

Kawasaki H

40

Male

+

AD

CEA

Med

LB and LND

None

126

Alive with recurrence

17

Yamasaki M

67

Male

+

AD

CEA

Med

EGFR-TKI

N/A

8

Alive without disease progression

18

Present case

56

Male

+

AD

CEA

Med

LND

CRT

32

Alive without recurrence

  1. TM tumor marker, AD adenocarcinoma, SQ squamous cell carcinoma, LA large cell carcinoma, Undif undifferentiated carcinoma, SCC squamous cell carcinoma antigen, CEA carcinoembryonic antigen, NSE neuron-specific enolase, Med mediastinum, LB lobectomy, LND lymph node dissection, PN pneumonectomy, CRT chemoradiation therapy, ALK anaplastic lymphoma kinase, EGFR epidermal growth factor receptor, TKI tyrosine kinase inhibitor, RTx radiation therapy