Lymph node cancer of the mediastinum with a putative necrotic primary lesion in the lung: a case report

Table 1 Cancers of the intrathoracic lymph nodes with unknown primary site

Case	Author	Age (years)	Sex	Smoking history	Histology	Elevated TMs	Location	Treatment	Adjuvant treatment	Follow-up (months)	Outcome
1	Morita Y	56	Male	+	SQ	None	Med	LB and LND	None	20	Alive without recurrence
2	Kohdono S	67	Male	+	LA	None	Med	Tumor resection	RTx	6	Died of recurrence
3	Kohdono S	58	Female	+	LA	CEA	Med	LB and LND	RTx	6	Alive with recurrence
4	Kohdono S	56	Male	+	Small	SCC	rt. Hilum	LB and LND	None	16	Alive without recurrence
5	Blanco N	56	Male	+	SQ	no data	Med	Tumor resection	CRT	No data	Alive without recurrence
6	Kawasaki H	69	Male	No data	LA	CEA	rt. Hilum	LB and LND	None	20	Alive without recurrence
7	Tomita M	56	Male	+	SQ	SCC	lt. Hilum	Tumor resection	None	32	Alive without recurrence
8	Miwa K	72	Male	+	SQ	CEA	Med	LND	RTx	82	Alive without recurrence
9	Miwa K	78	Male	+	AD	CEA	Med	LND	RTx	44	Alive without recurrence
10	Miwa K	70	Male	+	SQ	None	Med	CRT	N/A	33	Alive without disease progression
11	Miwa K	76	Male	+	Undifferentiated	CEA	Med	CRT	N/A	24	Alive without disease progression
12	Shiota Y	69	Male	+	AD	CEA	Med	CRT	N/A	22	Alive without disease progression
13	Harada H	83	Female	No data	AD	NSE	Med	Tumor resection	None	38	Alive without recurrence
14	Watanabe N	55	Female	–	AD	CEA	Med	ALK-TKI	N/A	3	Alive without disease progression
15	Kim M.J.	59	Male	+	SQ	None	rt. Hilum	PN and LND	CRT	No data	Alive without recurrence
16	Kawasaki H	40	Male	+	AD	CEA	Med	LB and LND	None	126	Alive with recurrence
17	Yamasaki M	67	Male	+	AD	CEA	Med	EGFR-TKI	N/A	8	Alive without disease progression
18	Present case	56	Male	+	AD	CEA	Med	LND	CRT	32	Alive without recurrence

TM tumor marker, AD adenocarcinoma, SQ squamous cell carcinoma, LA large cell carcinoma, Undif undifferentiated carcinoma, SCC squamous cell carcinoma antigen, CEA carcinoembryonic antigen, NSE neuron-specific enolase, Med mediastinum, LB lobectomy, LND lymph node dissection, PN pneumonectomy, CRT chemoradiation therapy, ALK anaplastic lymphoma kinase, EGFR epidermal growth factor receptor, TKI tyrosine kinase inhibitor, RTx radiation therapy

ISSN: 1477-7819