Table 2 Response, PFS, OS and toxicity rate

Response to treatment

n

%

p

 Complete response

3

4.7

 Partial response

50

78.1

 Stable disease

5

7.8

 Progressive disease

6

9.4

Wild-type KRAS and NRAS PFS

Months or %

%95 CI (min-max)

 Median follow-up

18.9

2.0–51.0

 Median PFS

13

9.6–16.4

 6-months PFS

77.3

 1-year PFS

50.1

 2-year PFS

16.9

 3-year PFS

3.4

 Median OS

26

23.1–29.2

 6-months OS

90.4

 1-year OS

79.5

 2-year OS

53.7

 3-year OS

31.1

 Right colon PFS

4

1.5–6.5

0.02

 Left colon PFS

14

10.8–17.2

 Right colon OS

18

5.3–30.7

0.02

 Left colon OS

26

23.1–28.9

 Yes PFS

17

14.3–19.7

0.02

 No PFS

8

5.6–10.4

 Yes OS

40

19.9–60.1

0.007

 No OS

22

17.7–26.4

 Synchronous PFS

12

7.0–17.0

0.28

 Metachronous PFS

17

3.6–30.4

 Synchronous OS

23

16.9–29.1

0.21

 Metachronous OS

26

21.7–30.3

Toxicity

Grade (all)

Grade (1–2)

Grade (3–4)

 Acne-like rash

%60.9

%54.6

%6.3

 Diarrhoea

%36.2

%31.5

%4.7

 Neutropenia

%34.7

%25.5

%9.2