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Table 3 Potential predictive factors and risk of SN metastases separately for center A and center B

From: Predictive factors for sentinel node metastases in primary invasive breast cancer: a population-based cohort study of 2552 consecutive patients

Determinants

Category

Center A

Center B

  

SN positive

SN negative

OR 95% CI

SN positive

SN negative

OR 95% CI

Screening

No

297

179

1.00

422

164

1.00

Yes

552

179

0.62(0.46–0.86)

571

133

0.63(0.47–0.88)

Unknown

39

16

0.82(0.42–1.60)

Age

≤ 50

157

86

1.00

180

76

1.00

51–74

620

237

1.02(0.59–1.78)

670

175

0.82(0.48–1.44)

≥ 75

111

51

0.69(0.34–1.39)

143

46

0.69(0.34–1.37)

Menopause status

Pre

167

90

1.00

181

74

1.00

Post < 5 years

91

29

0.67(0.34–1.29)

77

31

1.32(0.70–2.50)

Post ≥ 5 years

589

238

0.88(0.50–1.52)

710

184

0.77(0.43–1.34)

Unknown

41

17

0.81(0.40–1.67)

25

8

0.87(0.34–2.16)

Tumor size

T1

394

191

1.00

744

176

1.00

T2

136

105

1.63(1.16–2.30)

210

108

2.13(1.54–2.94)

T3 and T4

4

7

6.28(1.50–26.40)

9

5

1.48(0.44–4.90)

Unknown

354

71

0.60(0.42–0.84)

30

8

1.70(0.72–4.04)

Tumor type

Ductal

620

306

1.00

704

236

1.00

D and L

25

12

0.89(0.42–1.88)

10

5

1.20(0.38–3.79)

Lobular

80

45

0.90(0.58–1.40)

136

43

0.84(0.54–1.30)

Others

163

11

0.23(0.11–0.50)

143

13

0.30(0.17–0.57)

Histological grade

I

218

66

1.00

270

68

1.00

II

363

169

1.31(0.91–1.89)

444

136

0.80(0.56–1.16)

III

290

136

1.49(0.98–2.26)

273

91

0.80(0.51–1.24)

Unknown

17

3

1.30(0.31–5.37)

6

2

2.38(0.36–15.87)

Estrogen receptor

Positive

679

335

1.00

859

271

1.00

Negative

98

35

0.59(0.33–1.04)

120

26

0.72(0.38–1.40)

Unknown

111

4

0.07(0.00–1.04)

14

Progesterone receptor

Positive

578

290

1.00

742

241

1.00

Negative

199

79

0.71(0.48–1.08)

237

56

0.79(0.50–1.23)

Unknown

111

5

4.15(0.31–54.96)

14

HER-2

Negative

630

292

1.00

411

131

1.00

Positive

77

44

1.04(0.66–1.64)

97

22

0.63(0.37–1.10)

Unknown

181

38

0.93(0.59–1.50)

485

144

1.04(0.77–1.42)

Multifocality

No

452

194

1.00

732

192

1.00

Yes

93

71

1.58(1.07–2.32)

115

73

2.21(1.50–3.23)

Unknown

343

109

0.72(0.53–0.99)

146

32

0.88(0.56–1.40)

Vascular invasion

No

148

41

1.00

908

227

1.00

Yes

18

34

6.10(2.98–12.50)

69

63

3.04(2.03–4.57)

Unknown

722

299

1.64(1.10–2.44)

16

7

1.80(0.66–4.93)