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Table 3 Potential predictive factors and risk of SN metastases separately for center A and center B

From: Predictive factors for sentinel node metastases in primary invasive breast cancer: a population-based cohort study of 2552 consecutive patients

Determinants Category Center A Center B
   SN positive SN negative OR 95% CI SN positive SN negative OR 95% CI
Screening No 297 179 1.00 422 164 1.00
Yes 552 179 0.62(0.46–0.86) 571 133 0.63(0.47–0.88)
Unknown 39 16 0.82(0.42–1.60)
Age ≤ 50 157 86 1.00 180 76 1.00
51–74 620 237 1.02(0.59–1.78) 670 175 0.82(0.48–1.44)
≥ 75 111 51 0.69(0.34–1.39) 143 46 0.69(0.34–1.37)
Menopause status Pre 167 90 1.00 181 74 1.00
Post < 5 years 91 29 0.67(0.34–1.29) 77 31 1.32(0.70–2.50)
Post ≥ 5 years 589 238 0.88(0.50–1.52) 710 184 0.77(0.43–1.34)
Unknown 41 17 0.81(0.40–1.67) 25 8 0.87(0.34–2.16)
Tumor size T1 394 191 1.00 744 176 1.00
T2 136 105 1.63(1.16–2.30) 210 108 2.13(1.54–2.94)
T3 and T4 4 7 6.28(1.50–26.40) 9 5 1.48(0.44–4.90)
Unknown 354 71 0.60(0.42–0.84) 30 8 1.70(0.72–4.04)
Tumor type Ductal 620 306 1.00 704 236 1.00
D and L 25 12 0.89(0.42–1.88) 10 5 1.20(0.38–3.79)
Lobular 80 45 0.90(0.58–1.40) 136 43 0.84(0.54–1.30)
Others 163 11 0.23(0.11–0.50) 143 13 0.30(0.17–0.57)
Histological grade I 218 66 1.00 270 68 1.00
II 363 169 1.31(0.91–1.89) 444 136 0.80(0.56–1.16)
III 290 136 1.49(0.98–2.26) 273 91 0.80(0.51–1.24)
Unknown 17 3 1.30(0.31–5.37) 6 2 2.38(0.36–15.87)
Estrogen receptor Positive 679 335 1.00 859 271 1.00
Negative 98 35 0.59(0.33–1.04) 120 26 0.72(0.38–1.40)
Unknown 111 4 0.07(0.00–1.04) 14
Progesterone receptor Positive 578 290 1.00 742 241 1.00
Negative 199 79 0.71(0.48–1.08) 237 56 0.79(0.50–1.23)
Unknown 111 5 4.15(0.31–54.96) 14
HER-2 Negative 630 292 1.00 411 131 1.00
Positive 77 44 1.04(0.66–1.64) 97 22 0.63(0.37–1.10)
Unknown 181 38 0.93(0.59–1.50) 485 144 1.04(0.77–1.42)
Multifocality No 452 194 1.00 732 192 1.00
Yes 93 71 1.58(1.07–2.32) 115 73 2.21(1.50–3.23)
Unknown 343 109 0.72(0.53–0.99) 146 32 0.88(0.56–1.40)
Vascular invasion No 148 41 1.00 908 227 1.00
Yes 18 34 6.10(2.98–12.50) 69 63 3.04(2.03–4.57)
Unknown 722 299 1.64(1.10–2.44) 16 7 1.80(0.66–4.93)