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Table 2 Comparisons between the two cohorts reported by Cucchetti et al. and Qiao et al.

From: Need for normalization: the non-standard reference standard for microvascular invasion diagnosis in hepatocellular carcinoma

Items Cohort in Cucchetti et al.’s External validation cohort in Qiao et al.’s p value
Origin of patients University of Bologna (1999 to 2008) University of Bologna (2000 to 2011)
Age (years, mean ± SD) 62.8 ± 9.9 63.5 ± 9.4 0.40
Male (n/N) 193/250 227/293 0.98
HBV (n/N) 65/250 68/293 0.51
HCV (n/N) 164/250 202/293 0.47
Mean tumor size (cm, mean ± SD) 3.7 ± 1.8 3.9 ± 2.1 0.24
Moderate or poor tumor differentiation (n/N) 174/250 198/293 0.68
Patients with multiple tumors (n/N) 55/250 60/293 0.75
Liver cirrhosis (n/N) 250/250 232/293 < 0.05
CTP score (class C) (%) 9.2 0 < 0.05
AFP > 400 ng/ml (n/N) 25/250 69/293 < 0.05
MVI (n/N) 186/250 78/293 < 0.05
  1. Statistical analysis was performed using the MedCalc version 14.12.0 software program (MedCalc Software bvba, Ostend, Belgium)
  2. CTP score Child Pugh score, AFP alpha-fetoprotein, MVI microvascular invasion