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Table 1 Comparisons between the two cohorts reported by Huang et al.

From: Need for normalization: the non-standard reference standard for microvascular invasion diagnosis in hepatocellular carcinoma

Features Discovery cohort Validation cohort p value
Age (year, median (range)) 53.0(10–86)※ 53.0(12–92)※ 1.00
Male (n/N) 1305/1540 530/630 0.78
HBV (n/N) 1255/1540 527/630 0.25
Liver cirrhosis (n/N) 1268/1540 512/630 0.62
BCLC stage (B/N) 154/1540 59/630 0.73
AFP > 200 ng/dL (n/N) 593/1540 259/630 0.28
Mean tumor size (cm, mean ± SD) 5.3 ± 3.5 5.5 ± 3.7 0.23
Patients with multiple tumors (n/N) 199/1540 78/630 0.81
Encapsulation (complete/N) 733/1540 294/630 0.74
Tumor differentiation (III–IV/N) 421/1540 171/630 0.97
Types of resection (anatomic/non-anatomic) 1222/318 475/155 < 0.05
MVI (n/N) 389/1540 205/630 < 0.05
  1. Statistical analysis was performed using the MedCalc version 14.12.0 software program (MedCalc Software bvba, Ostend, Belgium)
  2. BCLC Barcelona Clinic Liver Cancer stage, AFP alpha-fetoprotein, MVI microvascular invasion
  3. ※Data of mean and range were transformed into mean ± SD approximately with SD = 1/4(upper range–lower range)