The extremity localized classic osteosarcomas have better survival than the axial non-classics

Table 3 Multivariate analysis for OS and EFS

Variable (Category)	OS			EFS
Variable (Category)	HR	95% CI	P	HR	95% CI	P
Age (≤ 40 year vs. > 40 year)	1.075	0.393–2.946	0.888	0.959	0.404–2.280	0.925
Tumor site (limb vs. axial)	0.221	0.080–0.609	0.004	0.286	0.123–0.666	0.004
Tumor size (≤ 8 cm vs. > 8 cm)	0.783	0.410–1.494	0.457	0.886	0.510–1.540	0.668
Metastasis (no vs. yes)	0.307	0.142–0.661	0.003	0.441	0.207–0.938	0.034
Surgery (salvage vs. amputation)	0.889	0.445–1.777	0.738	0.730	0.394–1.353	0.318

HR hazard ratio, CI confidence interval, OS overall survival, EFS event-free survival

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