
Baseline vs. 3 months

Baseline vs. 6 months

Baseline vs. 12 months

Baseline vs. 24 months


Patients^{†}

MD

Heterogeneity

Patients^{†}

MD

Heterogeneity

Patients^{†}

MD

Heterogeneity

Patients^{†}

MD

Heterogeneity


(groups)

(clinical relevance)

Tau^{2}

Chi ^{2}

I^{2}(%)

(groups)

(clinical relevance)

Tau^{2}

Chi ^{2}

I^{2}(%)

(groups)

(clinical relevance)

Tau^{2}

Chi ^{2}

I^{2}(%)

(groups)

(clinical relevance)

Tau^{2}

Chi ^{2}

I^{2}(%)


Physical function ^{‡}

1753

14.36 [11.77, 16.95]

2.88

P=0.09

58

1841

9.32 [5.36, 13.28]

11.17

P=0.001

81

1787

7.42 [4.80, 10.03]

3.29

P=0.10

53

1489

4.31 [3.27, 5.36]

1.87

P=0.17

46

3

Medium
   
4

Small
   
4

Small
   
2

Trivial
   
Role function ^{‡}

919

18.55 [3.14, 33.97]

175.01

P<0.00001

95

1007

10.01 [3.93, 23.94]

187.29

P<0.00001

95

899

9.07 [0.04, 18.18]

48.02

P=0.01

77

N/A

N/A

N/A

N/A

N/A

3

Medium
   
4

Small
   
3

Small
        
Emotional function ^{‡}

919

0.83 [8.45, 6.79]

36.33

P=0.003

82

1007

3.47 [8.88, 1.94]

19.65

P=0.02

68

899

2.05 [6.05, 1.95]

1.78

P=0.32

11

N/A

N/A

N/A

N/A

N/A

3

Trivial
   
4

Trivial
   
3

Trivial
        
Cognitive function ^{‡}

919

3.78 [4.16, 11.71]

41.8

P=0.0003

88

1007

2.02 [5.32, 9.36]

46.43

P<0.0001

87

899

4.14 [2.29, 10.57]

19.97

P=0.07

62

N/A

N/A

N/A

N/A

N/A

3

Small
   
4

Small
   
3

Small
        
Social function ^{‡}

919

11.31 [4.43, 27.05]

183.61

P<0.00001

95

1007

4.38 [8.20, 16.97]

149.24

P<0.00001

93

911

6.56 [2.03, 15.14]

41.72

P=0.02

75

N/A

N/A

N/A

N/A

N/A

3

Medium
   
4

Trivial
   
3

Trivial
        
Global QoL ^{‡}

1753

7.26 [5.88, 8.64]

3.85

P=0.15

48

1740

4.94 [2.95, 6.94]

1.04

P=0.25

28

1758

0.52 [4.67, 5.72]

21.2

P=0.0002

85

1489

0.11 [1.58, 1.36]

1.37

P=0.24

27

3

Small
   
3

Trivial
   
4

Trivial
   
2

Trivial
   
Dyspnea ^{‡}

1753

12.06 [15.97, 8.15]

7.67

P=0.02

74

1740

10.48 [15.13, 5.84]

12.28

P=0.003

83

1692

8.98 [13.20, 4.76]

9.56

P=0.01

77

1489

6.37 [7.23, 5.52]

2.87

P=0.09

65

3

Medium
   
3

Small
   
3

Small
   
2

Small
   
Pain ^{‡}

1753

13.85 [17.30, 10.40]

5.81

P=0.05

67

1845

11.36 [14.48, 8.23]

4.82

P=0.09

53

1853

5.04 [10.96, 0.87]

33.42

P<0.00001

86

1489

5.76 [12.71, 1.18]

23.29

P=0.0003

92

3

Medium
   
4

Small
   
5

Small
   
2

Small
   
Fatigue ^{‡}

1753

20.60 [24.12, 17.08]

5.74

P=0.06

64

1841

13.68 [19.58, 7.78]

26.49

P=0.0001

86

1787

9.27 [15.27, 3.27]

27.38

P=0.0001

85

1489

6.48 [10.74, 2.21]

7.79

P=0.02

80

3

Large
   
4

Medium
   
4

Small
   
2

Small
   
Insomnia ^{‡}

919

7.64 [11.52, 3.76]

2.53

P=0.28

21

906

4.48 [8.34, 0.63]
 
P=0.22

35

852

5.82 [10.08, 1.56]

0.05

P=0.82

0

N/A

N/A

N/A

N/A

N/A

3

Small
   
3

Small
   
2

Small
        
Anorexia ^{‡}

919

18.36 [32.27, 4.45]

129.55

P=0.0005

87

1007

6.71 [16.85, 3.43

87.85

P=0.0002

85

899

4.29 [9.73, 1.15]

8.92

P=0.21

36

N/A

N/A

N/A

N/A

N/A

3

Medium
   
4

Small
   
3

Small
        
Nausea and Vomiting ^{‡}

919

10.43 [19.51, 1.35]

56.71

P<0.0001

91

1007

6.06 [13.10, 0.97]

41.88

P<0.0001

86

899

5.20 [12.20, 1.81]

28.32

P=0.02

75

N/A

N/A

N/A

N/A

N/A

3

Small
   
4

Small
   
3

Trivial
        
Constipation ^{‡}

919

4.27 [7.21, 1.33]

1.48

P=0.48

0

1243

5.42 [8.26, 2.58]

3.22

P=0.20

38

804

3.10 [6.31, 0.10]
 
P=0.90

0

N/A

N/A

N/A

N/A

N/A

3

Trivial
   
3

Small
   
2

Trivial
        
Diarrhea ^{‡}

919

12.42 [20.99, 3.85]

43.7

P=0.01

77

906

13.44 [23.53, 3.34]

65.62

P=0.002

84

804

12.69 [15.97, 9.41]
 
P=0.40

0

N/A

N/A

N/A

N/A

N/A

3

Small
   
3

Small
   
2

Small
        
Financial ^{‡}

169

7.18 [13.71, 0.65]

1.06

P=0.30

6

167

6.51 [13.31, 0.29]
 
P=0.24

29

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

2

Small
   
2

Small
             
Dysphagia ^{§}

919

6.70 [17.38, 30.77]

440.55

P<0.00001

98

1007

7.11 [12.89, 27.10]

398.73

P<0.00001

97

899

4.51 [14.17, 5.14]

57.58

P=0.005

81

N/A

N/A

N/A

N/A

N/A

3

Small
   
4

Small
   
3

Trivial
        
Eating Problem ^{§}

919

5.85 [34.21, 22.50]

616.02

P<0.00001

98

1007

0.94 [21.86, 19.97]

440.12

P<0.00001

97

899

3.51 [12.05, 5.04]

43.43

P=0.01

78

N/A

N/A

N/A

N/A

N/A

3

Small
   
4

Trivial
   
3

Trivial
        
Reflux ^{§}

804

14.01 [39.88, 11.86]

339.53

P<0.00001

97

915

5.21 [19.44, 9.01]

148.13

P<0.00001

95

788

3.25 [6.87, 0.37]
 
P=0.72

0

N/A

N/A

N/A

N/A

N/A

2

Medium
   
3

Trivial
   
2

Trivial
        
PainOES18 ^{§}

804

0.46 [3.91, 4.84]

6.49

P=0.09

64

896

2.13 [2.65, 6.92]

11.24

P=0.05

66

788

0.31 [3.08, 3.69]

1.14

P=0.29

9

N/A

N/A

N/A

N/A

N/A

2

Trivial
   
3

Trivial
   
2

Trivial
        
Swallowing problem ^{§}

919

6.36 [14.87, 2.15]

45.68

P=0.003

83

906

5.05 [13.39, 3.29]

43.04

0.005

81

804

6.40 [17.92, 5.12]

61.41

P=0.004

88

N/A

N/A

N/A

N/A

N/A

3

Small
   
3

Small
   
2

Trivial
        
Dry mouth ^{§}

919

5.82 [11.64, 0.01]

13.73

P=0.13

51

906

5.66 [12.38, 1.06]

22.69

P=0.06

65

804

9.19 [13.24, 5.13]
 
P=0.30

5

N/A

N/A

N/A

N/A

N/A

3

Small
   
3

Small
   
2

Small
        
Taste problem ^{§}

919

10.26 [26.13, 5.61]

181.5

P<0.00001

93

906

6.75 [16.15, 2.65]

54.91

P=0.006

81

804

8.42 [12.46, 4.38]
 
P=0.28

14

N/A

N/A

N/A

N/A

N/A

3

Medium
   
3

Small
   
2

Small
        
Cough problem ^{§}

919

15.35 [25.20, 5.50]

56.49

P=0.02

76

906

12.05 [23.21, 0.88]

78.64

P=0.004

82

804

11.01 [18.89, 3.13]

19.56

P=0.13

55

N/A

N/A

N/A

N/A

N/A

3

Medium
   
3

Medium
   
2

Medium
        
Speech problem ^{§}

919

9.94 [12.68, 7.20]
 
P=0.15

48

906

8.45 [11.07, 5.84]

1.9

P=0.39

0

870

3.16 [9.25, 2.92]

17.59

P=0.08

60

N/A

N/A

N/A

N/A

N/A

3

Small
   
3

Small
   
3

Trivial
        
 N/A not applicable (this means that no two patient groups were available to derive a summary estimate of HRQL change by metaanalysis)
 MD Mean difference / mean change
 ^{†}The amount of patients in each analysis are the number of patients at baseline and the given followup time (e.g., the number of patients at 3 months followup represent the number of patients at baseline and the number of patients at 3 months followup, combined).
 ^{‡}Mean difference; measured by the QLQC30
 ^{§}Mean difference; measured by the QLQOES18
 'Sufficiently' homogenous estimates are presented in bold (I^{2} ≤50% AND P≥ 0.1)