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Table 3 Characteristics by SMI change groups

From: Loss of skeletal muscle mass during neoadjuvant treatments correlates with worse prognosis in esophageal cancer: a retrospective cohort study

 

SMI change

p

 

< − 2.98%

> − 2.98%

Number of patients (%)

57

 

58

  

Sex (%)

 Female

19

(33.3)

10

(17.2)

0.076

 Male

38

(66.7)

48

(82.8)

 

ECOG (%)

 0

15

(26.3)

25

(43.9)

0.108

 1

40

(70.2)

29

(50.9)

 

 2

2

(3.5)

3

(5.3)

 

Smoking status (%)

 Current smoker

20

(35.1)

12

(20.7)

0.086

 Ex-smoker

21

(36.8)

19

(32.8)

 

 Non-smoker

16

(28.1)

27

(46.6)

 

T stage

 1

2

(3.8)

0

(0.0)

0.549

 2

5

(9.3)

5

(8.6)

 

 3

42

(77.8)

44

(75.9)

 

 4

5

(9.3)

9

(15.5)

 

N stage

 0

14

(25.9)

19

(32.8)

0.445

 1

38

(70.4)

36

(62.1)

 

 2

1

(1.9)

3

(5.2)

 

 3

1

(1.9)

0

(0.0)

 

Cancer type (%)

 Adenocarcinoma

40

(70.2)

48

(82.8)

0.111

 SCC*

17

(29.8)

10

(17.2)

 

Pathological grade**

 1

3

(13.0)

6

(18.2)

0.790

 2

9

(39.1)

13

(39.4)

 

 3

12

(47.9)

14

(42.4)

 

Tumor location (%)

 Lower third

45

(78.9)

50

(86.2)

0.357

 Middle third

11

(19.3)

6

(10.3)

 

 Upper third

1

(1.8)

2

(3.4)

 

Neoadjuvant treatment (%)

 Chemoradiation

19

(33.3)

11

(19.0)

0.079

 Chemotherapy

38

(66.7)

47

(81.0)

 

Operation type (%)

 MIE

39

(68.4)

39

(67.2)

0.931

 Thoracotomy

13

(22.8)

13

(22.4)

 

 Hybrid-laparoscopy

2

(3.5)

3

(5.2)

 

 Hybrid-VATS

2

(3.5)

1

(1.7)

 

 Transhiatal

1

(1.8)

2

(3.4)

 

Preop. endo. treatment (%)

 Any

26

(45.6)

14

(24.1)

0.026

 Stent

23

(40.4)

12

(20.7)

0.037

 PEG§

2

(3.5)

2

(3.4)

1.000

 EMR

1

(1.8)

0

(0.0)

0.993

Age, years (mean [SD])

63

[9]

63

[9]

0.817

Height, cm (median [IQR])

173

[164,179]

174

[168,179]

0.350

Preop. weight, kg (mean [SD])

74

[17]

75

[16]

0.840

Weight loss, kg (median [IQR])

10

[0, 15]

6

[2, 10]

0.131

FEV1% (mean [SD])

89

[21]

92

[16]

0.527

Creatinine, umol/l (mean [SD])

70

[22]

72

[16]

0.484

CCI (median [IQR])

5

[5, 6]

5

[4, 6]

0.397

  1. *Squamous cell carcinoma
  2. **Grade not reported on all pathological reports
  3. †Minimally invasive esophagectomy
  4. ‡Video-assisted thoracoscopic surgery
  5. §Percutaneous endoscopic gastrostomy
  6. ¶Endoscopic mucosal resection