Table 3 Cox proportional hazard analysis of risk factors for adverse survival outcome
From: Significance of poor performance status after resection of colorectal liver metastases
Univariate | Multivariate | |||
|---|---|---|---|---|
Variable | HR (95% CI) | P value | HR (95% CI) | P value |
Male gender | 1.38 (0.91–2.10) | 0.125 | ||
Age | 1.00 (0.98–1.0) | 0.816 | ||
Smoking | 1.02 (0.63–1.67) | 0.931 | ||
Diabetes mellitus | 0.99 (0.53–1.86) | 0.986 | ||
Body mass index | 0.99 (0.94–1.05) | 0.841 | ||
ASA grade 3–4 | 1.40 (0.93–2.11) | 0.111 | ||
Rectal primary | 1.24 (0.83–1.87) | 0.292 | ||
Primary T4 | 1.63 (0.99–2.67) | 0.053 | 1.40 (0.84–2.34) | 0.197 |
Node positive primary | 1.70 (1.02–2.84) | 0.041 | 1.42 (0.83–2.46) | 0.203 |
Synchronous disease | 1.62 (1.08–2.45) | 0.021 | 1.77 (1.05–2.96) | 0.031 |
Preoperative chemotherapy | 1.72 (1.15–2.59) | 0.009 | 1.25 (0.75–2.08) | 0.394 |
Preoperative chemotherapy > 6 cycles | 1.57 (0.86–2.88) | 0.142 | ||
Major resection | 1.16 (0.78–1.71) | 0.461 | ||
Tumour size > 50 mm | 0.93 (0.48–1.79) | 0.826 | ||
Morbidity (Clavien-Dindo ≥ 3) | 1.68 (1.0–2.83) | 0.051 | 1.38 (0.70–2.70) | 0.352 |
WHO performance status, 0–2 vs > 2 | 0.45 (0.30–0.68) | < 0.001 | 0.52 (0.32–0.86) | 0.010 |