Table 2 Comparison between statin ‘recent’ users and ‘former/never’ used
From: Statin consumption as a risk factor for developing colorectal cancer: a retrospective case study
Characteristic | Statin recent users (n = 107) | Statin former/never used (n = 218) | p value |
|---|---|---|---|
Age (year) | 73.9 (SD 9.49) | 70.1 (SD 13.2) | 0.00751 |
Male gender (%) | 55.1 | 51.4 | 0.5232 |
Diabetes | < 0.00012 | ||
Yes (%) | 43.0 | 9.2 | |
Diagnosis (%) | 0.4402 | ||
Rectal cancer, C20 | 41.1 | 36.7 | |
Colon cancer, C18 | 58.9 | 63.3 | |
Smoking (%) | 0.1752 | ||
Never | 19.4 | 23.4 | |
Not currently | 18.3 | 23.4 | |
Currently | 11.8 | 8.6 | |
Prior | 50.5 | 39.9 | |
No info | N = 14 | N = 20 | |
Current smoker (%) | 0.3822 | ||
Yes | 11.8 | 8.6 | |
Use of NSAIDs (%) | 0.7432 | ||
Has used | 44.9 | 46.8 | |
Never/rare | 55.1 | 53.2 | |
Use of salicylic acid (%) | < 0.00012 | ||
Never/rare | 38.3 | 85.8 | |
Has used | 61.7 | 14.2 | |
BMI, kg/m2 | 0.00021 | ||
Mean | 27.8 | 25.6 | |
Median | 27.4 | 24.9 | |
IQR | 7.0 | 6.0 | |
BMI (kg/m2) (%) | 0.00013 | ||
< 24.9 | 31.1 | 50.2 | |
25–30 | 35.8 | 34.4 | |
> 30 | 33.0 | 15.3 | |
CRP at diagnosis, mg/L | 0.8873 | ||
Mean | 24.1 | 23.2 | |
Median | 6.0 | 6.0 | |
IQR | 22.1 | 20.9 | |
CRP > 10 mg/L (%) | 0.9912 | ||
Yes | 37.6 | 37.6 | |
Hb at diagnosis, g/L | 0.1531 | ||
Mean | 119 | 123 | |
Median | 122 | 126 | |
IQR | 32 | 31 | |
CEA at diagnosis, ng/mL | 0.7773 | ||
Mean | 154 | 29.5 | |
Median | 3.5 | 3.7 | |
IQR | 18.8 | 10.3 | |
CEA > 5 ng/mL (%) | 0.2702 | ||
Yes | 35.8 | 42.6 | |
Tumour, TNM (%) | 0.4993a | ||
TX | 8.6 | 4.2 | |
T1 | 2.9 | 4.7 | |
T2 | 15.2 | 13.5 | |
T3 | 55.2 | 54.0 | |
T4 | 18.1 | 23.7 | |
Nodes, TNM (%) | 0.8823b | ||
NX | 11.3 | 7.9 | |
N0 | 45.3 | 45.8 | |
N1 | 19.8 | 21.8 | |
N2 | 23.6 | 24.5 | |
Metastasis, TNM (%) | 0.4482 | ||
M0 | 76.6 | 80.3 | |
M1 | 23.4 | 19.7 | |
Stadium (%) | 0.7203 | ||
I | 14.6 | 14.1 | |
II | 29.1 | 30.7 | |
III | 32.0 | 34.1 | |
IV | 24.3 | 21.0 | |
Previous cancer diagnosis (%) | 0.6732 | ||
Yes | 13.1 | 11.5 | |
Heredity (%) | 0.4462 | ||
No/unknown | 92.5 | 89.0 | |
First-grade relative | 7.5 | 10.1 | |
Hereditary nonpolyposis CRC | – | 0.9 | |
Familial adenomatous polyposis | – | – | |
Hereditary CRC | – | – | |
Colitis (%) | 0.4372 | ||
No | 98.1 | 98.2 | |
Ulcerative colitis | – | 0.9 | |
Crohn | 0.9 | 0.5 | |
Ischaemic | – | 0.5 | |
Other | 0.9 | – | |
Systolic BP, mmHg | 0.4691 | ||
Mean | 139 | 137 | |
Median | 140 | 137 | |
IQR | 20.5 | 30 | |
Diastolic BP, mmHg | 0.0281 | ||
Mean | 77 | 80 | |
Median | 77.5 | 80 | |
IQR | 15 | 18 | |
Cholecystectomy (%) | 0.8212 | ||
Yes | 8.4 | 9.2 | |
Atherosclerosis (%) | < 0.0012 | ||
Yes | 43.9 | 6.4 | |
Myocardial infarction (%) | < 0.0012 | ||
Yes | 21.5 | 3.7 | |
Stroke (%) | < 0.0012 | ||
Yes | 20.6 | 4.6 | |
Alcoholism (%) | 0.4882 | ||
Yes | 1.9 | 3.2 |