Table 1 Characteristics of the study population (n = 260, diabetic patients excluded)
From: Statin consumption as a risk factor for developing colorectal cancer: a retrospective case study
Characteristic | Cases (n = 260) | Age group 20–64 years old (n = 73) |
|---|---|---|
Age (year) | 70.4 (SD 12.7) | – |
Male gender (%) | 51.2 | 54.8 |
Use of statins (%) | ||
Never | 71.9 | 80.8 |
Has used | 28.0 | 19.2 |
Recent (% of ever) | 84.9 | 92.9 |
Former (% of ever) | 15.1 | 7.1 |
Length of statin use (%) | ||
Short term | 27.4 | 21.4 |
Medium term | 13.7 | 28.6 |
Long term | 58.9 | 50.0 |
Type of statin use (%) | ||
Simvastatin | 52.1 | 71.4 |
Atorvastatin | 8.2 | 7.1 |
Mix of statins | 39.7 | 21.4 |
Diagnosis (%) | ||
Rectal cancer, C20 | 38.9 | 54.8 |
Colon cancer, C18 | 61.1 | 45.2 |
Use of NSAIDs (%) | ||
Never/rare | 56.2 | 60.3 |
Has used | 43.9 | 39.7 |
Recent (% of ever) | 40.4 | 44.8 |
Former (% of ever) | 59.7 | 55.2 |
Use of salicylic acid (%) | ||
Never/rare | 76.9 | 91.8 |
Has used | 23.1 | 8.2 |
Recent (% of ever) | 83.3 | 83.3 |
Former (% of ever) | 16.7 | 16.7 |
BMI (kg/m2) | ||
Mean | 25.7 (SD 4.5) | 26.7 (SD 4.5) |
Median | 25.1 | 26.3 |
IQR | 5.8 | 7.0 |
Smoking (%) | ||
Never | 23.4 | 16.2 |
Currently | 9.1 | 13.2 |
Prior | 42.4 | 27.9 |
Not currently | 25.1 | 42.6 |
Atherosclerosis (%) | ||
Yes | 15.0 | 4.1 |
Myocardial infarction (%) | ||
Yes | 8.1 | 2.7 |
Stroke (%) | ||
Yes | 8.1 | 1.4 |
Alcoholism (%) | ||
Yes | 3.5 | 6.8 |
Cholecystectomy (%) | ||
Yes | 8.9 | 2.7 |
CRP at diagnosis (mg/mL) | ||
Mean | 24.3 (SD 48.9) | 19.4 (SD 32.5) |
Median | 5.5 | 5.5 |
IQR | 21.8 | 15.4 |
CRP > 10 mg/mL (%) | ||
Yes | 37.3 | 30.9 |
Hb at diagnosis (g/L) | ||
Mean | 123 (SD 22.6) | 127 (SD 22.6) |
Median | 126 | 132 |
IQR | 29.3 | 34 |
CEA at diagnosis (ng/mL) | ||
Mean | 38.4 | 23.3 |
Median | 3.5 | 3.0 |
IQR | 11.9 | 12.0 |
CEA > 5 ng/mL (%) | ||
Yes | 41.0 | 36.2 |
Tumour, TNM (%) | ||
TX | 5.1 | 1.4 |
T1 | 5.1 | 5.7 |
T2 | 13.7 | 10.0 |
T3 | 53.5 | 60.0 |
T4 | 22.7 | 22.9 |
Nodes, TNM (%) | ||
NX | 8.2 | – |
N0 | 45.9 | 43.7 |
N1 | 22.2 | 25.4 |
N2 | 23.7 | 31.0 |
Metastasis, TNM (%) | ||
M0 | 79.6 | 76.7 |
M1 | 20.4 | 23.3 |
Stadium (%) | ||
I | 15.0 | 12.7 |
II | 30.1 | 26.8 |
III | 33.3 | 36.6 |
IV | 21.5 | 23.9 |
Previous cancer diagnosis (%) | ||
Yes | 10.4 | 2.7 |
Heredity (%) | ||
No/unknown | 89.2 | 86.3 |
First-grade relative | 10.0 | 12.3 |
Hereditary nonpolyposis colorectal cancer | 0.8 | 1.7 |
Familial adenomatous polyposis | – | – |
Hereditary CRC | – | – |
Colitis (%) | ||
No | 97.7 | 95.9 |
Ulcerative colitis | 0.8 | 1.4 |
Crohn | 0.8 | 1.4 |
Ischaemic | 0.4 | – |
Other | 0.4 | 1.4 |
Systolic BP (mmHg) | ||
Mean | 137 (SD 20.5) | 135 (SD 17.1) |
Median | 135.5 | 133.5 |
IQR | 28.3 | 26.5 |
Diastolic BP (mmHg) | ||
Mean | 79 (SD 11.8) | 83 (SD 10.4) |
Median | 80 | 85 |
IQR | 18.8 | 15 |