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Table 4 Multivariate analysis of factors associated with tumour recurrence, death from renal cancer and all-cause mortality following radical nephrectomy

From: Positive surgical margin following radical nephrectomy is an independent predictor of local recurrence and disease-specific survival

Variable

Local recurrence

Metastatic progression

 

HR

95% CI

P value

HR

95% CI

P value

Age

0.99

0.97–1.01

0.3

0.99

0.97–1.0

0.2

Gender

0.75

0.4–1.4

0.4

1.0

0.6–1.6

0.99

Tumour size

1.1

0.99–1.2

0.06

1.1

1.0–1.1

0.03

Central renal lesion

1.0

0.5–2.2

0.9

0.97

0.5–1.8

0.92

Positive surgical margins

4.8

2–11.6

0.001

2.1

0.96–4.4

0.06

Pathology

 Necrotic tumour

 Capsular invasion

1.1

2.1

0.6–2.2

1.1–4.2

0.7

0.03

2.3

1.4

1.3–3.8

0.8–2.4

0.001

0.2

Tumour stage (pT3–4 compared with pT1-T2)

3.1

1.4–7

0.005

3.6

2.0–6.5

0.001

Variable

All-cause mortality

Disease-specific mortality

 

HR

95% CI

P value

HR

95% CI

P value

Age

1.03

1.01–1.04

0.003

1.0

0.98–1.02

0.99

Gender

0.8

0.6–1.2

0.3

0.9

0.5–1.6

0.6

Tumour size

1.05

0.99–1.1

0.1

1.1

1.02–1.2

0.01

Central renal lesion

0.7

0.4–1.2

0.3

0.7

0.3–1.5

0.37

Positive surgical margins

1.3

0.6–2.9

0.5

2.4

1.1–5.5

0.03

Pathology

 Necrotic tumour

 Capsular invasion

2.0

1.3

1.3–2.9

0.8–1.9

0.001

0.2

2.2

1.9

1.2–4.0

1.0–3.5

0.01

0.05

Tumour stage (pT3–T4 compared with pT1–T2)

2.2

1.4–3.5

0.001

4.2

1.9–9.1

0.001