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Table 2 The GO_BP terms and pathways enriched for the upregulated genes (A) and the downregulated genes (B) involved in the most significant modules. GO, Gene Ontology; BP, biological process

From: Integrated network analysis to explore the key genes regulated by parathyroid hormone receptor 1 in osteosarcoma

Category

Term

Count

P value

Gene symbol

(A)

GO_BP

GO:0002376~immune system process

8

1.63E−07

C1QA, C1QB, CD86, LY86, FCGR1, THEMIS2, C1QC, CLEC4N

GO:0045576~mast cell activation

4

3.83E−07

CD48, FYB, FCGR2B, FCGR3

GO:0045087~innate immune response

7

4.62E−06

C1QA, C1QB, CYBB, LY86, FCGR1, C1QC, CLEC4N

GO:0006911~phagocytosis, engulfment

4

1.86E−05

FCGR2B, AIF1, FCGR1, FCGR3

GO:0006954~inflammatory response

5

5.96E−04

CYBB, AIF1, LY86, THEMIS2, CCL6

PATHWAY

mmu05150:Staphylococcus aureus infection

7

2.59E−10

C1QA, C1QB, FCGR2B, FCGR4, FCGR1, C1QC, FCGR3

mmu05322:Systemic lupus erythematosus

6

6.02E−06

C1QA, C1QB, CD86, FCGR4, FCGR1, C1QC

mmu04145:Phagosome

6

1.37E−05

CYBB, FCGR2B, FCGR4, CTSS, FCGR1, FCGR3

mmu05152:Tuberculosis

6

1.45E−05

FCGR2B, IL10RA, FCGR4, CTSS, FCGR1, FCGR3

mmu04380:Osteoclast differentiation

5

8.03E−05

CYBB, FCGR2B, FCGR4, FCGR1, FCGR3

(B)

GO_BP

GO:0016125~sterol metabolic process

8

4.60E−14

CYP51, LDLR, HMGCR, FDPS, HMGCS1, SREBF2, SC4MOL, DHCR24

GO:0008202~steroid metabolic process

9

5.23E−14

CYP51, LDLR, HMGCR, FDPS, HMGCS1, LSS, SREBF2, SC4MOL, DHCR24

GO:0008203~cholesterol metabolic process

7

6.80E−12

CYP51, LDLR, HMGCR, FDPS, HMGCS1, SREBF2, DHCR24

GO:0006694~steroid biosynthetic process

7

7.42E−12

CYP51, HMGCR, FDPS, HMGCS1, LSS, SC4MOL, DHCR24

GO:0016126~sterol biosynthetic process

6

1.69E−11

CYP51, HMGCR, FDPS, HMGCS1, SC4MOL, DHCR24

PATHWAY

mmu00100:Steroid biosynthesis

5

1.10E−08

CYP51, SQLE, LSS, SC4MOL, DHCR24

mmu00900:Terpenoid backbone biosynthesis

3

2.46E−04

HMGCR, FDPS, HMGCS1