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Table 3 Multivariate analysis of variables predictive for stage B HCC patient recurrence

From: Survival outcomes of hepatectomy for stage B Hepatocellular carcinoma in the BCLC classification

Recurrence

p value

Risk ratio

95% confidence interval

Albumin (g/dl), <4 vs ≥4

0.026

1.382

1.040

1.834

PIVKA-II (mAU/ml), ≤100 vs >1000

0.437

0.537

0.266

0.983

100–1000 vs >1000

0.038

1.479

1.023

2.127

100–1000 vs ≤100

0.002

2.755

1.447

5.717

AP-factor, AP1 vs AP2

0.036

2.102

1.049

4.548

     AP2 vs AP3

0.001

0.562

0.395

0.795

Tumor number, 1 vs 2,3

0.037

0.709

0.514

0.979

     1 vs ≥4

<0.001

0.485

0.326

0.739

Microscopic portal vein invasion, vp0 vs vp2

0.006

0.488

0.310

0.805

  1. PIVKA-II, protein induced by vitamin K absence or antagonism factor II; AP-factor, a product of the serum levels of AFP and PIVKA-II
  2. vp0: no tumor thrombus in the portal vein
  3. vp1: tumor thrombus distal to the second branches of the portal vein
  4. vp2: tumor thrombus in the second branches of the portal vein