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Table 5 Pattern of recurrence and oncologic outcomes of the relapsed patients

From: Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age

Arm

Age

Histology, grade, stage

RFI (M)

Relapse sites

Relapse pattern

Salvage treatment

Outcomes

RS.1

34

Endometrioid, G3, IC1

8.1

Vaginal stump, liver, bladder, diaphragm, ileum, ascending colon

Disseminated

RCRS + chemotherapy

DOD

RS.2

36

CCC, IA

10.3

Liver, pelvic mass

Disseminated

Chemotherapy

DOD

RS.3

37

Endometrioid, G1, IC1

14.6

Vaginal stump, rectal mass

Localized

Chemotherapy

DOD

RS.4

40

Mucinous,G1,IC1

51.7

Lung

Disseminated

Chemotherapy

AWD

RS.5

36

Endometrioid, G1, IC1

55.3

Vaginal stump, ileum, para-urethra

Localized

RCRS + chemotherapy + radiotherapy

AWD

RS.6

34

CCC, IC1

4.9

Systematic lymph nodes

Disseminated

Chemotherapy + radiotherapy

DOD

RS.7

40

CCC, IC3

57.3

Abdominopelvic cavity

Disseminated

Chemotherapy

DOD

RS.8

31

HGSC, IC1

4.2

Abdominopelvic cavity

Disseminated

Chemotherapy

DOD

RS.9

36

CCC, IC1

6.4

Abdominopelvic cavity

Disseminated

Palliative

DOD

FSS.1

24

Endometrioid, G3, IC3

57.1

Contralateral ovary

Localized

RCRS + chemotherapy

NED

FSS.2

34

Endometrioid, G1, IC1

67.4

Contralateral ovary

Localized

RCRS + chemotherapy

NED

FSS.3

29

Mucinous, G1, IC2

9.2

Contralateral ovary

Localized

RCRS + chemotherapy

AWD

FSS.4

22

Mucinous, G1, IC1

36.9

Lung

Disseminated

Chemotherapy + radiotherapy

DOD

FSS.5

25

Mucinous, G1, IC3

16.3

Contralateral ovary

Localized

RCRS + chemotherapy

NED

  1. RS radical surgery, FSS fertility-sparing surgery, CCC clear-cell carcinoma, RFI relapse-free intervals, DOD dead of the recorded disease, NED no evidence of disease, AWD alive with the recorded disease, RCRS re-cytoreductive surgery, HGSC high-grade serous carcinoma, TSS tumor-specific survival