Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age

Table 3 Risk factors related to TSS in stage I EOC patients of reproductive age

Variables	DOD		5 year-OS%	p value^a	p value^b	HR(95%CI)
Variables	Yes	No	5 year-OS%	p value^a	p value^b	HR(95%CI)
Type of surgery				0.048	0.469	0.38(0.03–5.34)
RS (reference)	7	49	87.2
FSS	1	51	97.3
Age				0.030	0.690	1.81(0.10–33.40)
≤ 30 years (reference)	1	54	97.6
> 30 years	7	46	86.3
Tumor size				0.495
≤ 12 cm (reference)	5	50	90.1
> 12 cm	3	50	93.9
Histology				0.074
Mucinous	1	51	97.5		0.195	11.38(0.29–450.86)
Serous	1	8	88.9		0.235	4.46(0.38–52.35)
Endometrioid	2	25	92.6		0.078	7.80(0.80–76.36)
CCC (reference)	4	16	78.5
Grade				< 0.001	0.007	38.92(2.68–565.45)
G1-2 (reference)	2	82	97.3
G3/CCC	6	18	73.9
FIGO stage				0.314
IA-B (reference)	1	35	97.2
IC1	6	49	88.6
IC2-3	1	16	90.0
Pretreatment tumor markers				0.430
Normal (reference)	3	52	94.5
Elevated	5	48	89.0
EAOC				0.024	0.343	2.34(0.40–13.59)
No (reference)	4	83	95.1
Yes	4	17	79.6

RS radical surgery, FSS fertility-sparing surgery, TSS tumor-specific survival, EOC epithelial ovarian cancer, CCC clear-cell carcinoma, EAOC endometriosis-associated ovarian cancer, DOD dead of the recorded disease, HR hazard ratios, CI confidence intervals
^aLog-rank test
^bCox proportional hazards model

ISSN: 1477-7819