Oncofertility in patients with stage I epithelial ovarian cancer: fertility-sparing surgery in young women of reproductive age

Table 2 Risk factors related to DFS in stage I EOC patients of reproductive age

Variables	Relapse		5 year-DFS%	p value^a	p value^b	HR(95%CI)
Variables	Yes	No	5 year-DFS%	p value^a	p value^b	HR(95%CI)
Type of surgery				0.423
RS (reference)	9	47	83.0
FSS	5	47	91.0
Age				0.106
≤ 30 years (reference)	4	51	91.7
> 30 years	10	43	81.9
Tumor size				0.878
≤ 12 cm (reference)	7	48	88.0
> 12 cm	7	46	85.2
Histology				0.467
Mucinous	4	48	91.5
Serous	1	8	88.9
Endometrioid	5	22	83.1
CCC (reference)	4	16	78.5
Grade				0.006	0.048	3.41(1.01–11.49)
G1-2 (reference)	7	77	92.0
G3/CCC	7	17	68.6
FIGO stage				0.053
IA-B (reference)	1	35	97.2
IC1	9	46	83.9		0.199	4.03(0.48–33.87)
IC2-3	4	13	70.6		0.325	3.35(0.30–37.41)
Pretreatment tumor markers				0.071	0.075	3.30(0.89–12.29)
Normal (reference)	4	51	92.2
Elevated	10	43	80.9
EAOC				0.002	0.092	2.56(0.86–7.63)
No (reference)	7	80	91.5
Yes	7	14	67.3

RS radical surgery, FSS fertility-sparing surgery, EOC epithelial ovarian cancer, CCC clear-cell carcinoma, EAOC endometriosis-associated ovarian cancer, DFS disease-free survival, HR: hazard ratios, CI confidence intervals
^aLog-rank test
^bCox proportional hazards model

ISSN: 1477-7819