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Table 4 Stratification analysis of the association between rs1859168 genotypes and pancreatic cancer risk

From: rs1859168 A > C polymorphism regulates HOTTIP expression and reduces risk of pancreatic cancer in a Chinese population

Variables rs1859168 (AA/AC + CC)
Patients Control OR (95%CI) P
Age
  < 60 81/327 68/370 0.78 (0.54–1.13) 0.184
  ≥ 60 104/409 68/415 0.67 (0.48–0.95) 0.025
Sex     
 Male 118/443 82/481 0.64 (0.47–0.88) 0.006
 Female 67/293 54/304 0.86 (0.57–1.30) 0.482
Body mass index
  < 23 81/324 64/363 0.73 (0.50–1.05) 0.092
  ≥ 23 104/412 72/422 0.72 (0.51–1.01) 0.058
Smoking status
 No 109/418 74/481 0.64 (0.46–0.89) 0.008
 Yes 76/318 62/304 0.84 (0.57–1.23) 0.364
Alcohol consumer
 No 103/434 85/450 0.82 (0.59–1.13) 0.220
 Yes 82/302 51/335 0.59 (0.40–0.87) 0.008
Hypertension
 No 136/514 97/601 0.64 (0.47–0.85) 0.003
 Yes 49/222 39/184 0.95 (0.59–1.54) 0.829
History of pancreatitis
 No 177/704 135/777 0.72 (0.56–0.93) 0.012
 Yes 8/32 1/8 0.90 (0.07–10.97) 0.937
History of diabetes mellitus
 No 148/593 123/720 0.72 (0.55–0.94) 0.015
 Yes 37/143 13/65 0.72 (0.35–1.48) 0.372
Family history of cancer
 No 170/704 132/775 0.72 (0.56–0.93) 0.011
 Yes 15/32 4/10 0.42 (0.10–1.87) 0.258
  1. ORs and P values were obtained from logistic regression models with adjustment for age, gender, body mass index, smoking status, alcohol intake, hypertension, history of pancreatitis, diabetes mellitus, and family history of cancer