rs1859168 A > C polymorphism regulates HOTTIP expression and reduces risk of pancreatic cancer in a Chinese population

Table 4 Stratification analysis of the association between rs1859168 genotypes and pancreatic cancer risk

Variables	rs1859168 (AA/AC + CC)
Variables	Patients	Control	OR (95%CI)	P
Age
< 60	81/327	68/370	0.78 (0.54–1.13)	0.184
≥ 60	104/409	68/415	0.67 (0.48–0.95)	0.025
Sex
Male	118/443	82/481	0.64 (0.47–0.88)	0.006
Female	67/293	54/304	0.86 (0.57–1.30)	0.482
Body mass index
< 23	81/324	64/363	0.73 (0.50–1.05)	0.092
≥ 23	104/412	72/422	0.72 (0.51–1.01)	0.058
Smoking status
No	109/418	74/481	0.64 (0.46–0.89)	0.008
Yes	76/318	62/304	0.84 (0.57–1.23)	0.364
Alcohol consumer
No	103/434	85/450	0.82 (0.59–1.13)	0.220
Yes	82/302	51/335	0.59 (0.40–0.87)	0.008
Hypertension
No	136/514	97/601	0.64 (0.47–0.85)	0.003
Yes	49/222	39/184	0.95 (0.59–1.54)	0.829
History of pancreatitis
No	177/704	135/777	0.72 (0.56–0.93)	0.012
Yes	8/32	1/8	0.90 (0.07–10.97)	0.937
History of diabetes mellitus
No	148/593	123/720	0.72 (0.55–0.94)	0.015
Yes	37/143	13/65	0.72 (0.35–1.48)	0.372
Family history of cancer
No	170/704	132/775	0.72 (0.56–0.93)	0.011
Yes	15/32	4/10	0.42 (0.10–1.87)	0.258

ORs and P values were obtained from logistic regression models with adjustment for age, gender, body mass index, smoking status, alcohol intake, hypertension, history of pancreatitis, diabetes mellitus, and family history of cancer

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