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Table 2 Randomized controlled trials comparing D1 with D2 nodal dissection [43]

From: Evolution in the surgical management of gastric cancer: is extended lymph node dissection back in vogue in the USA?

Study Country Comparison Postoperative morbidity Postoperative mortality 5-year survival
Dent et al. (1982–1985) South Africa D1 (n = 22) 22% 0% 69%
D2 (n = 21) 43% 0% 67%
Bonenkamp et al. (1989–1993) Netherlands D1 (n = 380) 25% 4% 45%
D2 (n = 331) 43% 10% 47%
(P < 0.001) (P = 0.004) HR 1.00 (95%CI, 0.82–1.22)
Cuschieri et al. (1987–1994) UK D1 (n = 200) 28% 6.5% 35%
D2 (n = 200) 46% 13% 33%
(P < 0.001) (P = 0.04) HR 1.10 (95%CI, 0.87–1.39)
Degiuli et al. (1999–2002) Italy D1 (n = 76) 10.5% 1.3%  
D2 (n = 86) 16.3% 0%
(P < 0.029) (n.s.)
Degiuli et al. (1998–2005) Italy D1 (n = 133) 12% 3.0% 66.5
D2 (n = 134) 17.9% 2.2% 64.2
(P = 0.183) (P = 0.725) (P = 0.695)