Table 2 Randomized controlled trials comparing D1 with D2 nodal dissection [43]
Study | Country | Comparison | Postoperative morbidity | Postoperative mortality | 5-year survival |
|---|---|---|---|---|---|
Dent et al. (1982–1985) | South Africa | D1 (n = 22) | 22% | 0% | 69% |
D2 (n = 21) | 43% | 0% | 67% | ||
Bonenkamp et al. (1989–1993) | Netherlands | D1 (n = 380) | 25% | 4% | 45% |
D2 (n = 331) | 43% | 10% | 47% | ||
(P < 0.001) | (P = 0.004) | HR 1.00 (95%CI, 0.82–1.22) | |||
Cuschieri et al. (1987–1994) | UK | D1 (n = 200) | 28% | 6.5% | 35% |
D2 (n = 200) | 46% | 13% | 33% | ||
(P < 0.001) | (P = 0.04) | HR 1.10 (95%CI, 0.87–1.39) | |||
Degiuli et al. (1999–2002) | Italy | D1 (n = 76) | 10.5% | 1.3% |  |
D2 (n = 86) | 16.3% | 0% | |||
(P < 0.029) | (n.s.) | ||||
Degiuli et al. (1998–2005) | Italy | D1 (n = 133) | 12% | 3.0% | 66.5 |
D2 (n = 134) | 17.9% | 2.2% | 64.2 | ||
(P = 0.183) | (P = 0.725) | (P = 0.695) |