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Table 2 Summary estimates of diagnostic criteria and their 95% confidence intervals

From: Diagnostic significance of microRNAs as novel biomarkers for bladder cancer: a meta-analysis of ten articles

Sub-groups Sensitivity Specificity Positive LR Negative LR DOR AUC
(95%CI) (95%CI) (95%CI) (95%CI) (95%CI) (95%CI)
Ethnicity       
 Asian 0.83 (0.78–0.87) 0.84 (0.77–0.89) 5.2 (3.5–7.8) 0.21 (0.15–0.28) 25 (13–48) 0.90 (0.87–0.92)
 Caucasian 0.68 (0.61–0.73) 0.74 (0.68–0.79) 2.6 (2.0–3.3) 0.44 (0.36–0.54) 6 (4–9) 0.76 (0.73–0.80)
MiRNA profiling       
 Single miRNAs 0.65 (0.60–0.70) 0.73 (0.68–0.78) 2.5 (2.0–3.1) 0.47 (0.40–0.56) 5 (4–8) 0.74 (0.70–0.78)
 Multiple miRNAs 0.87 (0.82–0.91) 0.84 (0.74–0.91) 5.6 (3.3–9.3) 0.15 (0.11–0.20) 36 (22–61) 0.92 (0.89–0.84)
Sample types       
 Blood-based 0.79 (0.68–0.87) 0.90 (0.85–0.93) 7.7 (5.2–11.3) 0.23 (0.15–0.37) 33 (16–65) 0.90 (0.87–0.93)
 Urine-based 0.70 (0.64–0.75) 0.72 (0.67–0.77) 2.5 (2.0–3.1) 0.42 (0.34–0.53) 6 (4–9) 0.77 (0.73–0.80)
Sample size       
 >40 0.70 (0.64–0.76) 0.75 (0.69–0.80) 2.8 (2.1–3.7) 0.40 (0.31–0.52) 7 (4–12) 0.79 (0.75–0.82)
 ≤40 0.74 (0.66–0.81) 0.81 (0.70–0.89) 3.9 (2.4–6.3) 0.32 (0.24–0.43) 12 (6–23) 0.80 (0.76–0.83)
Overall 0.72 (0.66–0.76) 0.76 (0.71–0.81) 3.0 (2.4–3.8) 0.37 (0.30–0.46) 8 (5–12) 0.80 (0.77–0.84)
  1. CI confidence interval, LR likelihood ratio, DOR diagnostic odds ratio, AUC area under the curve