Table 1 Main characteristics of eight articles included in this meta-analysis
First author | Year | Country | Ethnicity | Sample size | Mean age | Patient spectrum | Source of control | Detecting method | MicroRNAs | Specimen | QUADAS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Cases | Controls | ||||||||||
Zhou X | 2014 | China | Asian | 112 | 78 | 65 | 62 | Urothelial carcinoma of the bladder | Healthy individuals and patients with benign urological diseases | RT-qPCR | miR-106b | Urine | 6 |
Zhang DZ | 2014 | China | Asian | 50 | 21 | 75 | 65 | Bladder urothelial cell carcinoma | Patients absence of malignancies and hematuria | RT-qPCR | miR-99a, miR-125b | Urine | 4 |
Jiang XM | 2014 | China | Asian | 120 | 120 | 63 | 63 | Bladder cancer | Patients without bladder cancer | RT-qPCR | miR-152, miR-148b-3p, miR-3187-3p, miR-15b-5p, miR-27a-3p, miR-30a-5p | Serum | 4 |
Jiang XM | 2014 | China | Asian | 110 | 110 | 66 | 66 | Bladder cancer | Patients without bladder cancer | RT-qPCR | miR-152, miR-148b-3p, miR-3187-3p, miR-15b-5p, miR-27a-3p, miR-30a-5p | Serum | 4 |
Tölle A | 2013 | Germany | Caucasian | 20 | 20 | 43 | 69 | Bladder cancer | Healthy individuals and patients with benign urological diseases | RT-qPCR | miR-26b-5p, miR-144-5p, miR-374-5p | Blood | 5 |
Tölle A | 2013 | Germany | Caucasian | 20 | 19 | 43 | 69 | Bladder cancer | Healthy individuals and patients with benign urological diseases | RT-qPCR | miR-520e, miR-618, miR-1255b-5p | Urine | 5 |
Mengual L | 2013 | Spain | Caucasian | 151 | 126 | 72 | 63 | Bladder urothelial cell carcinoma | Controls without history of UCC | RT-qPCR | miR-25, miR-18a, miR-187 miR-204, miR-142-3p, miR-140-5p | Urine | 3 |
Adam L | 2013 | USA | Caucasian | 20 | 18 | 65 | 42 | Bladder cancer | Patients without urologic malignancies | RT-qPCR | multiple miRNAs | Plasma | 3 |
Miah S | 2012 | UK | Caucasian | 68 | 53 | 72 | 62 | Bladder urothelial cell carcinoma | Patients without history of UCC | RT-qPCR | miR-15a, miR-15b, miR-21, miR-23b, miR-24-1, miR-27b, miR-100, miR-133b, miR-135b, miR-183, miR-203, miR-211, miR-212, miR-328, miR-1224-3p | Urine | 5 |
Snowdon J | 2012 | Canada | Caucasian | 5 | 3 | 76 | 63 | Bladder cancer | Healthy control patients without history of urothelial cancer | RT-qPCR | miR-125b, miR-126 | Urine | 5 |