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Table 1 Main characteristics of eight articles included in this meta-analysis

From: Diagnostic significance of microRNAs as novel biomarkers for bladder cancer: a meta-analysis of ten articles

First author Year Country Ethnicity Sample size Mean age Patient spectrum Source of control Detecting method MicroRNAs Specimen QUADAS
Cases Controls Cases Controls
Zhou X 2014 China Asian 112 78 65 62 Urothelial carcinoma of the bladder Healthy individuals and patients with benign urological diseases RT-qPCR miR-106b Urine 6
Zhang DZ 2014 China Asian 50 21 75 65 Bladder urothelial cell carcinoma Patients absence of malignancies and hematuria RT-qPCR miR-99a, miR-125b Urine 4
Jiang XM 2014 China Asian 120 120 63 63 Bladder cancer Patients without bladder cancer RT-qPCR miR-152, miR-148b-3p, miR-3187-3p, miR-15b-5p, miR-27a-3p, miR-30a-5p Serum 4
Jiang XM 2014 China Asian 110 110 66 66 Bladder cancer Patients without bladder cancer RT-qPCR miR-152, miR-148b-3p, miR-3187-3p, miR-15b-5p, miR-27a-3p, miR-30a-5p Serum 4
Tölle A 2013 Germany Caucasian 20 20 43 69 Bladder cancer Healthy individuals and patients with benign urological diseases RT-qPCR miR-26b-5p, miR-144-5p, miR-374-5p Blood 5
Tölle A 2013 Germany Caucasian 20 19 43 69 Bladder cancer Healthy individuals and patients with benign urological diseases RT-qPCR miR-520e,
miR-618, miR-1255b-5p
Urine 5
Mengual L 2013 Spain Caucasian 151 126 72 63 Bladder urothelial cell carcinoma Controls without history of UCC RT-qPCR miR-25, miR-18a, miR-187
miR-204, miR-142-3p, miR-140-5p
Urine 3
Adam L 2013 USA Caucasian 20 18 65 42 Bladder cancer Patients without urologic malignancies RT-qPCR multiple miRNAs Plasma 3
Miah S 2012 UK Caucasian 68 53 72 62 Bladder urothelial cell carcinoma Patients without history of UCC RT-qPCR miR-15a, miR-15b, miR-21, miR-23b, miR-24-1, miR-27b, miR-100, miR-133b, miR-135b, miR-183, miR-203, miR-211, miR-212, miR-328, miR-1224-3p Urine 5
Snowdon J 2012 Canada Caucasian 5 3 76 63 Bladder cancer Healthy control patients without history of urothelial cancer RT-qPCR miR-125b, miR-126 Urine 5
  1. QUADAS score ≥6 indicated high quality, QUADAS score 4–6 indicated moderate quality, QUADAS score ≤3 indicated low quality
  2. UCC urothelial cell carcinoma, RT-qPCR quantitative reverse transcription polymerase chain reaction, QUADAS quality assessment of diagnostic accuracy studies