Table 3 Stratified analyses of the MPO-463G > A polymorphism on cancer risk by ethnicity and source of control group
From: Association between MPO-463G > A polymorphism and cancer risk: evidence from 60 case-control studies
Variables | A vs. G | AA vs. GG | AA vs. AG + GG | AA + AG vs. GG | ||||
|---|---|---|---|---|---|---|---|---|
OR (95%CI) | I 2 | OR (95%CI) | I 2 | OR (95%CI) | I 2 | OR (95%CI) | I 2 | |
Total | 0.90(0.854-1.069) | 0.571 | 0.84(0.76-0.94) | 0.417 | 0.89(0.83-0.95) | 0.520 | 0.87(0.78-0.97) | 0.366 |
Ethnicity | ||||||||
Caucasian | 0.90(0.84–0.97) | 0.576 | 0.85(0.76–0.96) | 0.506 | 0.91(0.84–0.98) | 0.533 | 0.87(0.78–0.98) | 0.484 |
Asian | 0.86(0.75–0.98) | 0.597 | 0.75(0.57–0.98) | 0.353 | 0.84(0.73–0.96) | 0.516 | 0.80(0.61–1.05) | 0.242 |
Other | 1.05(0.86–1.27) | 0.000 | 1.03(0.64–1.67) | 0.000 | 1.08(0.85–1.37) | 0.000 | 0.98(0.61–1.57) | 0.000 |
Lung cancer | ||||||||
Caucasian | 0.956(0.84–0.97) | 0.524 | 1.082(0.888–1.319) | 0.573 | 1.050(0.749–1.472) | 0.593 | 0.950(0.878–1.029) | 0.420 |
Asian | 0.863(0.691–1.078) | 0.551 | 0.641(0.370–1.110) | 0.013 | 0.709(0.400–1.256) | 0.000 | 0.861(0.740–1.002) | 0.495 |
Other | 0.861(0.715–1.037) | 0.176 | 0.567(0.363–0.886) | 0.000 | 0.558(0.360–0.867) | 0.000 | 0.926(0.758–1.132) | 0.467 |
Digestive Cancer | ||||||||
Caucasian | 0.704(0.474–1.045) | 0.796 | 0.609(0.291–1.274) | 0.620 | 0.751(0.514–1.100) | 0.428 | 0.658(0.423–1.024) | 0.756 |
Asian | 0.706(0.537–0.928) | 0.613 | 0.640(0.271–1.512) | 0.533 | 0.785(0.507–1.215) | 0.491 | 0.669(0.512–0.875) | 0.474 |
Resource | ||||||||
Population | 0.91(0.83–0.99) | 0.541 | 0.90(0.77–1.05) | 0.453 | 0.91(0.81–1.01) | 0.518 | 0.91(0.78–1.06) | 0.461 |
Hospital | 0.89(0.81–0.98) | 0.603 | 0.79(0.68–0.93) | 0.400 | 0.88(0.80–0.98) | 0.543 | 0.83(0.71–0.96) | 0.301 |
Others | 0.86(0.69–1.08) | 0.625 | 0.87(0.57–1.33) | 0.525 | 0.86(0.68–1.08) | 0.503 | 0.90(0.59–1.36) | 0.111 |
HWE | ||||||||
Yes | 0.89(0.83–0.96) | 0.598 | 0.88(0.77–0.96) | 0.454 | 0.88(0.81–0.95) | 0.507 | 0.92(0.81–1.04) | 0.373 |
No | 0.91(0.81–1.02) | 0.434 | 0.75(0.61–0.93) | 0.167 | 0.93(0.79–1.10) | 0.607 | 0.74(0.60–0.91) | 0.297 |