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Table 3 Results of subgroup analyses

From: Feasibility and diagnostic performance of dual-tracer-guided sentinel lymph node biopsy in cT1-2N0M0 gastric cancer: a systematic review and meta-analysis of diagnostic studies

  Number of studies Identification rate (95% CI) P Sensitivity (95% CI) P
Preoperative T stage
 cT1 12 0.979 (0.923–1.035) 0.00 0.861 (0.786–0.917) 0.22
 cT2 2 0.963 (0.751–1.176) 0.00 0.943 (0.808–0.993) 0.51
Number of SLNs
 <5 11 0.839 (0.760–0.900) 0.07
 ≥5 8 0.944 (0.882–0.979) 0.84
Method of SLN biopsy
 Pick up 13 0.973 (0.959–0.988) 0.01 0.869 (0.810–0.915) 0.11
 Basin dissection 6 0.949 (0.925–0.974) 0.66 0.959 (0.860–0.995) 0.39
Type of dual tracers
99mTc tin colloid + isosulfan blue 3 0.971 (0.960–0.982) 0.77 0.884 (0.810–0.937) 0.07
99mTc tin colloid + ICG 3 0.889 (0.779–1.000) <.001 0.826 (0.612–0.950) 0.34
99mTc tin colloid + patent blue violet 5 0.962 (0.933–0.992) 0.93 0.880 (0.688–0.975) 0.31
99mTc-HSA + ICG 2 0.932 (0.890–0.977) 0.62 1.00 (0.735–1.000) >0.99
99mTc-antimony sulfur colloid + ICG 2 0.932 (0.882–0.985) 0.38 1.00 (0.846–1.000) >0.99
Time performing SLN biopsy after dye injection
 ≥15 min 9 0.973 (0.958–0.989) 0.10 0.952 (0.898–0.982) 0.71
 <15 min 10 0.962 (0.939–0.986) 0.03 0.810 (0.719–0.882) 0.33
Method for intraoperative histological evaluation of SLN
 HE 7 0.908 (0.849–0.950) 0.11
 HE + IHC 8 0.864 (0.750–0.940) 0.08
Methods of surgery
 Opening surgery 7 0.976 (0.965–0.988) >.99 0.867 (0.786–0.925) 0.06
 Laparoscopic surgery 10 0.939 (0.907–0.972) 0.04 0.909 (0.813–0.969) 0.13
Country
 Japan 12 0.980 (0.973–0.988) 0.54 0.896 (0.837–0.939) 0.31
 Not in Japan 7 0.934 (0.891–0.978) 0.01 0.873 (0.773–0.940) 0.03
Year of studies
 ≥2013 7 0.976 (0.963–0.990) 0.06 0.905 (0.843–0.949) 0.15
 <2013 12 0.955 (0.931–0.980) 0.07 0.864 (0.774–0.928) 0.11
  1. SLN sentinel lymph node, P P value of heterogeneity, CI confidence interval, ICG indocyanine green, 99m Tc-HSA T99mc-human serum albumin, HE hematoxylin eosin, IHC immunohistochemistry