Table 1 Expression of MSi markers in colorectal carcinoma and its correlation with clinico-pathological features
Characteristics | No loss of expression n = 66 | Loss of expression of all markers n = 7 | MLH1/PMS2 loss n = 16 | MSH2/MSH6 loss n = 6 | Isolated MLH1 loss n = 5 | Total n = 100 | p value |
|---|---|---|---|---|---|---|---|
Age | |||||||
 <50 years | 27(41%) | 2(28.5%) | 5(31%) | 3(50%) | 0(0%) | 37 | 0.374 |
 >50 year | 39(59%) | 5(71%) | 11(68%) | 3(50%) | 5(100%) | 63 | |
Gender | |||||||
 Male | 29(44%) | 4(57%) | 10(62%) | 6(100%) | 2(40%) | 51 | 0.082 |
 Female | 37(56%) | 3(43%) | 6(37%) | 0(0%) | 3(60%) | 49 | |
Laterality | |||||||
 Right | 14(21%) | 2(29%) | 6(37%) | 4(66%) | 4(80%) | 30 | 0.013 |
 Left | 52(79%) | 5(71%) | 10(62%) | 2(33%) | 1(20%) | 70 | |
Lymphovascular invasion | |||||||
 Present | 19(28.7%) | 1(14%) | (12%) | 1(16%) | 4(80%) | 27 | 0.043 |
 Absent | 47(71%) | 6(86%) | 14(88%) | 5(84%) | 1(20%) | 73 | |
T stage | |||||||
 T1 | 1(1.5%) | 0(0%) | 0(0%) | 0(0%) | 0(0%) | 1 | 0.835 |
 T2 | 3(4.5%) | 1(14%) | 2(12.5%) | 1(16%) | 0(0%) | 7 | |
 T3 | 55(83%) | 4(57%) | 13(81%) | 5(84%) | 4(80%) | 81 | |
 T4 | 7(10%) | 2(29%) | 1(6.2%) | 0(0%) | 1(20%) | 11 | |
N stage | |||||||
 N0 | 20(30%) | 3(43%) | 6(37.5%) | 3(50%) | 0(0%) | 32 | 0.561 |
 N1 | 21(31%) | 1(14%) | 6(37.5%) | 1(16%) | 1(20%) | 30 | |
 N2a | 11(16%) | 1(14%) | 4(25%) | 1(16%) | 2(40%) | 19 | |
 N2b | 14(21%) | 2(29%) | 0(0%) | 1(16%) | 2(40%) | 19 | |
Tumor grade | |||||||
 I | 1(1.5%) | 1(14%) | 1(6.2%) | 0(0%) | 0(0%) | 3 | 0.487 |
 II | 50(76%) | 3(43%) | 14(87%) | 4(66%) | 3(60%) | 74 | |
 III | 15(23%) | 3(43%) | 1(6.2%) | 2(33%) | 2(40%) | 23 | |
Tumor type | |||||||
 NOS | 56(84.8%) | 4(57%) | 15(94%) | 3(50%) | 2(40%) | 80 | 0.177 |
 Mucinous | 7(12.5%) | 2(28.5%) | 1(6%) | 2(33%) | 2(40%) | 14 | |
 Medullary | 0(0%) | 0(0%) | 0(0%) | 1(16%) | 0(0%) | 1 | |
 Signet ring | 3(4.5%) | 1(14%) | 0(0%) | 0(0%) | 1(20%) | 5 | |