Table 1 Univariate analysis of clinicopathological characteristics on the size of mLN
Characteristics | pN1mic (n = 198) | pN1mac (n = 237) | p |
|---|---|---|---|
Gender | 0.183 | ||
Male (27.4%) | 48 (24.2%) | 71 (30.0%) | |
Female (72.6%) | 150 (75.8%) | 166 (70.0%) | |
Age of diagnosis (years) | |||
Mean age (±SD), year | 46.5 (±11.5) | 45.4 (±12.1) | 0.104 |
<45 years | 88 (44.4%) | 113 (47.7%) | 0.5 |
≥45 years | 110 (55.6%) | 124 (52.3%) | |
Primary tumor size | |||
Mean size (±SD), cm | 1.04 (±0.7) | 1.38 (±0.9) | 0.03 |
≤1 cm | 132 (66.7%) | 132 (55.7%) | 0.02 |
>1 cm | 66 (33.3%) | 105 (44.3%) | |
PTC variant | 0.066 | ||
Classic | 148 (74.7%) | 196 (82.7%) | |
Follicular v. | 15 (7.6%) | 8 (3.4%) | |
Tall cell v. | 20 (10.1%) | 13 (5.5%) | |
Diffuse sclerosing v. | 1 (0.5%) | 4 (1.7%) | |
Others | 14 (7.1%) | 16 (6.8%) | |
Multifocality | 0.306 | ||
(−) | 89 (44.9%) | 95 (40.1%) | |
(+) | 109 (55.1%) | 142 (59.9%) | |
Extrathyroidal extension | 0.125 | ||
Absent (40.0%) | 87 (43.9%) | 87 (36.7%) | |
Present (60.0%) | 111 (56.1%) | 150 (63.3%) | 0.05 |
Minimally | 100 (90.1%) | 122 (81.3%) | |
Grossly | 11 (9.9%) | 28 (18.7%) | |
Mean number of mLN | 2.21 (±1.9) | 5.47 (±4.5) | <0.001 |
L/N ratio | <0.001 | ||
≤0.5 (78.9%) | 174 (87.9%) | 169 (71.3%) | |
>0.5 (21.1%) | 24 (12.1%) | 68 (28.7%) | |
T stage | 0.009 | ||
T1a | 90 (45.5%) | 75 (31.6%) | |
T2 | 2 (1.0%) | 10 (4.2%) | |
T3 | 105 (53.0%) | 151 (63.7%) | |
T4a | 1 (0.5%) | 1 (0.4%) | |
BRAF mutation | 0.15 | ||
Absent (12.6%) | 30 (15.2%) | 25 (10.5%) | |
Present (87.4%) | 168 (84.8%) | 212 (89.5%) | |
Stimulation Tg | |||
Mean sTg (±SD), ng/ml | 1.27 (±4.8) | 2.54 (±8.9) | 0.02 |
<1 ng/ml | 158 (79.8%) | 167 (70.5%) | 0.026 |
≥1 ng/ml | 40 (20.2%) | 70 (29.5%) | |