Table 4 Univariate and multivariate analyses of prognostic factors for overall survival and disease-specific survival in patients aged 74 years or younger (n = 249)
From: Prognostic factors for gastrectomy in elderly patients with gastric cancer
Overall survival | Disease-specific survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||||
n | MST (months) | Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | MST (months) | Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
Sex | – | – | – | 0.204 | – | – | – | – | 0.246 | – | – |
Males | 185 | – | 1.96 (0.75–6.72) | – | – | – | – | 2.35 (0.65–15.04) | – | – | – |
Females | 64 | – | 1.00 | – | – | – | – | 1.00 | – | – | – |
ASA-PS | – | – | – | <0.001* | – | 0.274 | – | – | 0.777 | – | – |
1 | 180 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | – | – |
2 | 56 | – | 2.37 (0.90–5.69) | – | 2.17 (0.09–6.14) | – | – | 0.74 (0.11–2.72) | – | – | – |
3 | 13 | 76.4 | 6.62 (1.86–18.61) | – | 3.23 (0.50–16.85) | – | – | 1.74 (0.09–8.97) | – | – | – |
Surgery | – | – | – | 0.023* | – | 0.932 | – | – | 0.023* | – | 0.935 |
DG | 84 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
TG | 63 | 96.9 | 1.29 (0.55–2.96)) | – | 1.20 (0.44–3.28) | – | – | 0.76 (0.24–2.15) | – | 1.95 (0.3–11.86) | – |
LADG | 80 | – | 0.17 (0.03–0.61) | – | 0.69 (0.09–3.72) | – | – | 2.67e−10 (0–0.23) | – | 1.75e−8 (0–83.40) | – |
Cardiectomy | 15 | – | 0.33 (0.01–1.66) | – | 1.19 (0.06–9.75) | – | – | 2.67e−10 (0–1.00) | – | (0-NC) | – |
LR | 7 | – | 3.17e−9 (1.12e−55–2.10) | – | 7.82e−9 (4.43e−54–13.53) | – | – | 2.67e−10 (9.69e−301–2.97) | – | 0.20 (4.22e−59-NC) | – |
Histology | – | – | – | 0.205 | – | – | – | – | 0.066 | – | – |
Intestinal | 110 | – | 1.00 | – | – | – | – | 1.00 | – | – | – |
Diffuse | 139 | – | 1.70 (0.76–4.15) | – | – | – | – | 3.08 (0.98–13.52) | – | – | – |
Tumor size (cm) | – | – | – | 0.002* | – | 0.637 | – | – | <0.001* | – | 0.810 |
<5 cm | 172 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
≥5 cm | 77 | – | 3.19 (1.47–7.03) | – | 1.32 (0.41–4.11) | – | – | 10.63 (3.37–46.69) | – | 0.76 (0.08–8.99) | – |
Depth of invasion (T) | – | – | – | <0.001* | – | 0.172 | – | – | <0.001* | – | 0.013* |
T1 | 154 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
T2 | 33 | – | 2.29 (0.48–8.69) | – | 0.64 (0.08–4.25) | – | – | 1.75e9 (0.80–9.06e145) | – | 1.22e9 (0.01–2.39e139) | – |
T3 | 23 | – | 4.04 (0.85–15.42) | – | 1.27 (0.18–8.21) | – | – | 2.70e9 (1.24–1.54e260) | – | 5.48e9 (0.03–3.32e96) | – |
T4 | 39 | – | 13.16 (5.23–37.50) | – | 3.02 (0.65–17.33) | – | – | 2.41e10 (31.03–1.23e144) | – | 6.14e10 (0.89–1.81e81) | – |
Lymphatic invasion (ly) | – | – | – | 0.045* | – | 0.189 | – | – | 0.003* | – | 0.009* |
ly0, ly1 | 192 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
ly2, ly3 | 57 | – | 2.94 (1.31–6.41) | – | 0.37 (0.07–1.60) | – | – | 4.20 (1.50–12.00) | – | 0.05 (0.01–0.51) | – |
Venous invasion (v) | – | – | – | 0.005* | – | 0.815 | – | – | 0.029* | – | 0.271 |
v0, v1 | 198 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
v2, v3 | 51 | – | 2.95 (1.29–6.43) | – | 0.87 (0.26–2.88) | – | – | 2.99 (1.00–8.29) | – | 0.40 (0.07–2.02) | – |
Lymph node metastasis (N) | – | – | – | <0.001* | – | 0.008* | – | – | <0.001* | – | <0.001* |
N0 | 180 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
N1 | 30 | – | 4.24 (1.42–11.76) | – | 1.96 (0.41–8.34) | – | – | 24.94 (3.69–487.50) | – | 27.56 (1.97–1080.37) | – |
N2 | 20 | – | 2.66 (0.41–10.38) | – | 0.94 (0.11–5.91) | – | – | 21.84 (2.09–470.13) | – | 13.89 (0.94–453.66) | – |
N3 | 19 | 66.1 | 14.93 (5.71–39.31) | – | 10.55 (1.99-73.65) | – | 66.1 | 97.33 (17.79–807.31) | – | 208.72 (10.54–14986.60) | – |
Clavien–Dindo | – | – | – | 0.654 | – | – | – | – | 0.235 | – | – |
0 | 220 | – | 1.00 | – | – | – | – | 1.00 | – | – | – |
I | 6 | – | 2.09 (0.12–10.05) | – | – | – | – | 3.65 (0.20–18.82) | – | – | – |
II | 11 | – | 2.09 (0.33–7.15) | – | – | – | – | 1.91 (0.10–9.82) | – | – | – |
III | 11 | – | 2.18 (0.35–7.46) | – | – | – | – | 4.27 (0.66–15.93) | – | – | – |
IV | 1 | – | 1.17e−7 (0–86.79) | – | – | – | – | 2.27e−7 (0–143.14) | – | – | – |
Onodera PNI | – | – | – | <0.001* | – | 0.091 | – | – | 0.008* | – | 0.261 |
<40 | 18 | 86.8 | 8.25 (3.17–19.21) | – | 4.92 (0.76–25.22) | – | – | 4.75 (1.07–15.12) | – | 6.47 (0.22–158.87) | – |
≥40 | 231 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
Modified GPS | – | – | – | <0.001* | – | 0.328 | – | – | <0.001* | – | 0.865 |
0 | 227 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
1 | 10 | – | 2.98 (0.47–10.34) | – | 3.61 (0.49–16.92) | – | – | 2.44 (0.13–12.55) | – | 1.31 (0.05-14.33) | – |
2 | 12 | 36.3 | 15.12 (5.34–37.46) | – | 2.20 (0.25–14.83) | – | – | 10.52 (2.34–34.66) | – | 2.32 (0.04–35.52) | – |
Chemotherapy | – | – | <0.001* | – | 0.196 | – | – | <0.001* | – | 0.038* | |
Yes | 67 | – | 1.00 | – | 1.00 | – | – | 1.00 | – | 1.00 | – |
No | 182 | – | 5.87 (2.68–13.49) | – | 2.84 (0.57–13.55) | – | – | 45.67 (9.16–827.80) | – | 43.58 (1.20-3226.69) | – |