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Table 4 Univariate and multivariate analyses of prognostic factors for overall survival and disease-specific survival in patients aged 74 years or younger (n = 249)

From: Prognostic factors for gastrectomy in elderly patients with gastric cancer

   Overall survival Disease-specific survival
    Univariate analysis Multivariate analysis   Univariate analysis Multivariate analysis
  n MST (months) Hazard ratio (95% CI) p value Hazard ratio (95% CI) p value MST (months) Hazard ratio (95% CI) p value Hazard ratio (95% CI) p value
Sex 0.204 0.246
 Males 185 1.96 (0.75–6.72) 2.35 (0.65–15.04)
 Females 64 1.00 1.00
ASA-PS <0.001* 0.274 0.777
 1 180 1.00 1.00 1.00
 2 56 2.37 (0.90–5.69) 2.17 (0.09–6.14) 0.74 (0.11–2.72)
 3 13 76.4 6.62 (1.86–18.61) 3.23 (0.50–16.85) 1.74 (0.09–8.97)
Surgery 0.023* 0.932 0.023* 0.935
 DG 84 1.00 1.00 1.00 1.00
 TG 63 96.9 1.29 (0.55–2.96)) 1.20 (0.44–3.28) 0.76 (0.24–2.15) 1.95 (0.3–11.86)
 LADG 80 0.17 (0.03–0.61) 0.69 (0.09–3.72) 2.67e−10 (0–0.23) 1.75e−8 (0–83.40)
 Cardiectomy 15 0.33 (0.01–1.66) 1.19 (0.06–9.75) 2.67e−10 (0–1.00) (0-NC)
 LR 7 3.17e−9 (1.12e−55–2.10) 7.82e−9 (4.43e−54–13.53) 2.67e−10 (9.69e−301–2.97) 0.20 (4.22e−59-NC)
Histology 0.205 0.066
 Intestinal 110 1.00 1.00
 Diffuse 139 1.70 (0.76–4.15) 3.08 (0.98–13.52)
Tumor size (cm) 0.002* 0.637 <0.001* 0.810
 <5 cm 172 1.00 1.00 1.00 1.00
 ≥5 cm 77 3.19 (1.47–7.03) 1.32 (0.41–4.11) 10.63 (3.37–46.69) 0.76 (0.08–8.99)
Depth of invasion (T) <0.001* 0.172 <0.001* 0.013*
 T1 154 1.00 1.00 1.00 1.00
 T2 33 2.29 (0.48–8.69) 0.64 (0.08–4.25) 1.75e9 (0.80–9.06e145) 1.22e9 (0.01–2.39e139)
 T3 23 4.04 (0.85–15.42) 1.27 (0.18–8.21) 2.70e9 (1.24–1.54e260) 5.48e9 (0.03–3.32e96)
 T4 39 13.16 (5.23–37.50) 3.02 (0.65–17.33) 2.41e10 (31.03–1.23e144) 6.14e10 (0.89–1.81e81)
Lymphatic invasion (ly) 0.045* 0.189 0.003* 0.009*
 ly0, ly1 192 1.00 1.00 1.00 1.00
 ly2, ly3 57 2.94 (1.31–6.41) 0.37 (0.07–1.60) 4.20 (1.50–12.00) 0.05 (0.01–0.51)
Venous invasion (v) 0.005* 0.815 0.029* 0.271
 v0, v1 198 1.00 1.00 1.00 1.00
 v2, v3 51 2.95 (1.29–6.43) 0.87 (0.26–2.88) 2.99 (1.00–8.29) 0.40 (0.07–2.02)
Lymph node metastasis (N) <0.001* 0.008* <0.001* <0.001*
 N0 180 1.00 1.00 1.00 1.00
 N1 30 4.24 (1.42–11.76) 1.96 (0.41–8.34) 24.94 (3.69–487.50) 27.56 (1.97–1080.37)
 N2 20 2.66 (0.41–10.38) 0.94 (0.11–5.91) 21.84 (2.09–470.13) 13.89 (0.94–453.66)
 N3 19 66.1 14.93 (5.71–39.31) 10.55 (1.99-73.65) 66.1 97.33 (17.79–807.31) 208.72 (10.54–14986.60)
Clavien–Dindo 0.654 0.235
 0 220 1.00 1.00
 I 6 2.09 (0.12–10.05) 3.65 (0.20–18.82)
 II 11 2.09 (0.33–7.15) 1.91 (0.10–9.82)
 III 11 2.18 (0.35–7.46) 4.27 (0.66–15.93)
 IV 1 1.17e−7 (0–86.79) 2.27e−7 (0–143.14)
Onodera PNI <0.001* 0.091 0.008* 0.261
 <40 18 86.8 8.25 (3.17–19.21) 4.92 (0.76–25.22) 4.75 (1.07–15.12) 6.47 (0.22–158.87)
 ≥40 231 1.00 1.00 1.00 1.00
Modified GPS <0.001* 0.328 <0.001* 0.865
 0 227 1.00 1.00 1.00 1.00
 1 10 2.98 (0.47–10.34) 3.61 (0.49–16.92) 2.44 (0.13–12.55) 1.31 (0.05-14.33)
 2 12 36.3 15.12 (5.34–37.46) 2.20 (0.25–14.83) 10.52 (2.34–34.66) 2.32 (0.04–35.52)
Chemotherapy   <0.001* 0.196 <0.001* 0.038*
 Yes 67 1.00 1.00 1.00 1.00
 No 182 5.87 (2.68–13.49) 2.84 (0.57–13.55) 45.67 (9.16–827.80) 43.58 (1.20-3226.69)
  1. DG distal gastrectomy, TG total gastrectomy, LADG laparoscopic-assisted distal gastrectomy, LR local resection, PNI prognostic nutritional index, GPS Glasgow prognostic score, ASA-PS American Society of Anesthesiologists-Physical Status
  2. p values indicated by (*) are statistically significant (p < 0.05) NC means “not calculated”
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