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Table 3 Univariate and multivariate analyses of prognostic factors for overall survival and disease-specific survival in patients aged 75 years or older (n = 117)

From: Prognostic factors for gastrectomy in elderly patients with gastric cancer

   Overall survival Disease-specific survival
    Univariate analysis Multivariate analysis   Univariate analysis Multivariate analysis
  n MST (months) Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value MST (months) Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Sex 0.229 0.890
 Males 82 74.0 1.16 (0.63–2.24) 1.00
 Females 35 70.8 1.00 1.18 (0.44–3.68)
ASA-PS 0.041* 0.014* 0.002*
 1 30 1.00 1.00 1.00
 2 65 80.2 1.29 (0.64–2.71) 1.12 (0.33–4.31) 0.14 (0.01–1.53)
 3 22 34.3 2.88 (1.30–6.47) 3.58 (1.06–13.87) 9.11 (1.20–103.77)
Surgery 0.040* 0.636 0.036* 0.476
 DG 50 70.8 1.00 1.00 1.00 1.00
 TG 23 32.4 1.54 (0.73–3.07) 1.35 (0.52–3.32) 1.72 (0.51–5.18) 2.48 (0.20–26.78)
 LADG 25 0.36 (0.08–1.07) 0.68 (0.14–2.43) 1.18e−9 (0–0.65) 1.33e−9 (0–28.12)
 Cardiectomy 11 33.0 2.54 (1.09–5.44) 1.75 (0.62–4.62) 50.6 3.46 (1.03–10.56) 0.23 (0.02–2.35)
 LR 8 0.87 (0.13–3.00) 0.71 (0.10–3.20) 1.16e−9 (5.39e−16–7.35e−130) 5.54e−10 (0–24.97)
Histology 0.420 0.134
 Intestinal 76 74.0 1.00 1.00
 Diffuse 41 51.6 1.30 (0.72–2.30) 2.24 (0.88–5.87)
Tumor size 0.018* 0.793   0.003* 0.358
 <5 cm 68 80.2 1.00 1.12 (0.46–2.81) 1.00 2.69 (0.31–23.75)
 ≥5 cm 49 50.5 1.93 (1.09–3.47) 1.00 3.68 (1.38–11.49) 1.00
Depth of invasion (T) <0.001* 0.317 <0.001* 0.005*
 T1 57 80.2 1.00 1.00 1.00 1.00
 T2 18 88.8 0.54 (0.15–1.47) 0.30 (0.06–1.09) 1.26e−8 (0–15.07) 2.86e−10 (0–2.92)
 T3 20 38.4 2.16 (1.01–4.48) 0.65 (0.18–2.15) 20.02 (3.55–374.36) 15.44 (1.16–642.77)
 T4 22 25.2 2.50 (1.22–5.03) 0.87 (0.27–2.61) 50.5 33.63 (6.43–617.14) 10.86 (0.65–432.23)
Lymphatic invasion (ly) 0.013* 0.328 0.013* 0.578
 ly0, ly1 73 88.8 1.00 1.00 1.00 1.00
 ly2, ly3 43 41.3 2.29 (1.29–4.08) 1.49 (0.66–3.34) 3.90 (1.51–11.21) 1.79 (0.22–14.91)
Venous invasion (v) 0.001* 0.944 <0.001* 0.013*
 v0, v1 77 80.2 1.00 1.00 1.00 1.00
 v2, v3 40 37.2 2.18 (1.22–3.87) 1.02 (0.44–2.26) 50.6 11.97 (3.94–51.74) 9.38 (6.56–82.05)
Lymph node metastasis (N) <0.001* 0.178 <0.001* 0.010*
 N0 73 88.8 1.00 1.00 1.00 1.00
 N1 20 41.3 2.91 (1.29–6.58) 2.41 (0.84–6.84) 51.6 6.30 (1.89–24.18) 5.40 (0.67–55.78)
 N2 13 3.19 (1.25–7.71) 0.92 (0.18–3.80) 1.65e−8 (0–3.37) 8.07e−11 (0–1.20)
 N3 11 17.9 8.82 (4.21–19.22) 3.76 (0.86–15.50) 25.2 28.24 (7.99–115.80) 6.70 (0.34–219.73)
Clavien–Dindo <0.001* <0.001* <0.001* <0.001*
 0 97 70.8 1.00 1.00 1.00 1.00
 I 5 0.86 (0.14–2.84) 0.52 (0.07–2.21) 1.24 (0.06–6.35) 0.24 (0.01–3.42)
 II 6 88.8 0.28 (0.01–1.32) 0.82 (0.04–5.79) 6.15e−9 (0–2.07) 12.78 (0–5.28e298)
 III 5 37.2 1.81 (0.43–5.05) 2.33 (0.44–10.33) 1.92 (0.10–9.83) 1.09 (0.01–104.71)
 IV 1 7.7 27.25 (1.39–184.77) 7.69 (0.35–67.41) 7.7 8.73e16 (18.30–1.89e109) 8.31e18 (15.71-NC)
 V 3 1.1 5.21e10 (87.65–1.64e31) 1.08e11 (57.71–9.25e141) 1.1 7.72e31 (255.05-NC) 5.71e33 (296.06–3.28e306)
Onodera PNI <0.001* 0.056 0.010* 0.698
 <40 29 33.0 2.65 (1.47–4.69) 2.03 (0.97–4.17) 2.35 (0.86–5.98) 1.42 (0.23–9.56)
 ≥40 88 80.2 1.00 1.00 1.00 1.00
Modified GPS 0.375 0.574
 0 96 70.8 1.00 1.00
 1 7 0.82 (0.13–2.71) 1.24 (0.06–6.21)
 2 14 34.3 1.54 (0.66–3.15) 1.59 (0.36–4.89)
Chemotherapy 0.562 0.252
 Yes 24 50.6 1.00 1.00
 No 93 74.0 1.42 (0.74–2.60) 2.77 (1.05–7.03)
  1. DG distal gastrectomy, TG total gastrectomy, LADG laparoscopic-assisted distal gastrectomy, LR local resection, PNI prognostic nutritional index, GPS Glasgow prognostic score, ASA-PS American Society of Anesthesiologists-Physical Status
  2. P values indicated by (*) are statistically significant (P < 0.05) NC means “not calculated”
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