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Fig. 3 | World Journal of Surgical Oncology

Fig. 3

From: Lipid raft-mediated miR-3908 inhibition of migration of breast cancer cell line MCF-7 by regulating the interactions between AdipoR1 and Flotillin-1

Fig. 3

miR-3908 suppresses cell growth and clonogenicity in MCF-7 cells. For evaluating the overexpressed or underexpressed possible biotic outcomes induced by miR-3908, several functional experiments were performed in MCF-7 cells. Compared with control cells, proliferation of MCF-7 cells (a) would be suppressed by transfection with miR-3908. Moreover, the inhibitors of miR-3908 accentuated the same process in MCF-7 cells (a). Furthermore, the colony formation assay revealed that miR-3908 played a significant role in the suppression of this ability compared with the control group in MCF-7 cells. However, downregulation of miR-3908 facilitated significantly the colony-forming ability of MCF-7 cells. These results suggested that miR-3908 also lowered colony formation of MCF-7 cells (b) (P < 0.001). The data are presented as means ± SD from three independent experiments. *P < 0.05, **P < 0.01

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