Table 6 Literature review for the relationship of CRP level and survival in OSCC patients
From: Roles of preoperative C-reactive protein are more relevant in buccal cancer than other subsites
Authors/year | Tumor sites/nations | Case no. | Cut-off point, tumor stage | Disease-free survival (DFS) | Overall survival (OS) |
|---|---|---|---|---|---|
Jablonska E. et al. (1997) [5] | OSCC/Poland | 42 | Compares mean values, significant difference between stages IV vs II (p < 0.01) | NA | NA |
Khandavilli S.D. et al. (2009) [36] | OSCC/United Kingdom | 60 | CRP > 5.0 mg/L; significant with tumor stage, p = 0.046 | NA | Significant in OS (p < 0.001) (multivariate) |
Kruse A.L. et al. (2010) [37] | OSCC/Switzerland | 278 | CRP > 5.0 mg/L; NA | No significant difference (p = 0.137) | Not significant in time to metastasis (p = 0.468) |
Chen, H.H. et al. (2011) [6] | OSCC/Taiwan | 59 | CRP ≥ 5.0 mg/L, significant with tumor stage, p = 0.005 | Significant difference in 2-year DFS, p < 0.001 | Significant difference in 2-year OS, p = 0.013 |
Grimm, M. et al. (2012) [45] | OSCC/Germany | 187 | CRP ≥ 1.1 mg/L; LPI significantly correlated with advanced tumor stage, p = 0.0002a | 5-year DFS, p < 0.0001 | NA |
Huang SF et al. (2012) [7] | OSCC/Taiwan | 142 | CRP ≥ 5.0 mg/L, significantly related with tumor stage, p = 0.001 | 3-year DFS, p < 0.001 | 3-year OS, p = 0.008 |
Peter F. et al. (2013) [38] | HNSCC/Germany | 261 | CRP ≥ 2.0 mg/L, significant with advanced tumor stage, p = 0.006; nodal status, p = 0.045 | NA | 5-year OS, p < 0.0001 |
Chen, I.H. et al. (2014) [39] | OSCC/Taiwan | Recurrent OSCC, 100 | CRP ≥ 5.0 mg/L, significant with tumor stage, p < 0.001 | NA | Mean 33.53 months, OS significantly different, p < 0.001 |
Farhan-Alanie, O.M. et al. (2015) [40] | OSCC and soft palatal ca/ United Kingdom | 178 | Modified Glasgow scale: combined albumin (<35 g/L) and CRP (>10 mg/L) level | Modified Glasgow scale related with cancer-specific survival (p < 0.001) | Modified Glasgow scale related with overall survival (p < 0.001) |