Expression and clinicopathologic significance of TUFM and p53 for the normal–adenoma–carcinoma sequence in colorectal epithelia

Table 2 Relationship between TUFM and p53 expression and clinicopathological parameters in colorectal adenomas

Variables	TUFM		P value	p53		P value
Variables	+	−	P value	+	−	P value
Gender
Male	46	68	P = 0.486	26	88	P = 0.801
Female	20	23		9	34
Age (years)
<45	9	13	P = 0.923	4	18	P = 0.717
45 ≤ n < 60	26	33		12	47
n ≥ 60	31	45		19	57
Tumor size (cm)
d < 1 cm	39	64	P = 0.083	16	87	P = 0.001
1 cm ≤ d < 2 cm	13	19		6	26
d ≥ 2 cm	14	8		13	9
Number of tumor
n = 1	45	67	P = 0.456	24	88	P = 0.681
n ≥ 2	21	24		11	34
Location
Left side^a	35	58	P = 0.115	21	72	P = 0.883
Right side^b	20	27		11	36
Both sides	11	6		3	14
Histological type
Tubular	34	68	P = 0.028	14	88	P = 0.001
Villous	15	11		14	12
Tubulovillous	12	8		5	15
Serrated	5	4		2	7
Dysplasia
Mild	28	64	P = 0.001	0	92	P = 0.001
Moderate	7	11		3	15
Severe	31	16		32	15

P < 0.05, statistically significant
^aThe left side comprises the splenic flexture, descending and sigmoid colon, and rectum
^bThe right side comprises the cecum, ascending colon, hepatic flexure, and transverse colon

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