Fig. 2

Immunohistochemical staining for TUFM and p53 in tissues representing the colorectal adenoma–carcinoma sequence. a–d TUFM was absent from colorectal normal mucosa and showed positive expression in lesions of different grades of dysplasia. e, f Normal colorectal mucosa and mildly dysplastic adenoma displaying negative p53 staining. g Several scattered cells of moderate adenomas displaying p53 staining. h Severe dysplasia adenoma or adenoma with cancer transformation exhibiting intense immunopositivity for p53 (a–h; ×100)