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Table 2 Lymph node involvement and clinicopathological characteristics of pT1 IAC and SCC patients, n (%)

From: Association of lymph node involvement with the prognosis of pathological T1 invasive non-small cell lung cancer

Histology IAC P value SCC P value
pN0 (n = 220) pN (+) (n = 33) pN0 (n = 43) pN (+) (n = 29)
Age (mean), yrs.
 ≤60 90 (40.9) 17 (51.5) 0.263 11 (25.6) 12 (41.4) 0.201
 >60 130 (59.1) 16 (48.5)   32 (74.4) 17 (58.6)  
Gender
 Male 104 (47.3) 15 (44.5) 0.854 41 (95.3) 27 (93.1) 1.00
 Female 116 (52.7) 18 (54.5)   2 (4.7) 2 (6.9)  
Tobacco smoking history
 Never 139 (63.2) 20 (60.6) 0.847 8 (18.6) 5 (17.2) 1.00
 Ever/current 81 (36.8) 13 (39.4)   35 (81.4) 24 (82.8)  
CEA level (n = 395)
 <5.0 IU/mL 183 (83.2) 14 (42.4) <0.0001 33 (76.7) 20 (69.0) 0.587
 ≥5.0 IU/mL 37 (16.8) 19 (57.6)   10 (23.3) 9 (31.0)  
Tumor location
 Upper lobe 131 (59.5) 18 (54.6) 0.145 23 (53.5) 14 (48.3) 0.760
 Middle lobe 17 (7.7) 3 (9.1)   1 (2.3) 2 (6.9)  
 Lower lobe 72 (32.7) 11 (33.3)   15 (34.9) 9 (31.0)  
 Middle-lower lobe 0 1 (3.0)   4 (9.3) 4 (13.8)  
Type of surgery
 Lobectomy 197 (89.5) 27 (81.8) 0.236 38 (88.4) 26 (89.7) 0.591
 Limited resection 23 (10.5) 6 (18.2)   5 (11.6) 3 (10.3)  
Adjuvant chemotherapy
 No 146 (66.4) 0 <0.0001 20 (46.5) 0 <0.0001
 Yes 74 (33.6) 33 (100.0)   23 (53.5) 29 (100.0)  
Tumor size, cm
 ≤1.0 27 (12.3) 0 0.015 1 (2.3) 0 1.00
 1.0–≤2.0 136 (61.8) 18 (54.5)   17 (39.5) 11 (37.9)  
 2.0–≤3.0 57 (25.9) 15 (45.5)   25 (58.2) 18 (62.1)  
  1. CEA carcinoembryonic antigen, IAC invasive lung adenocarcinoma, SCC squamous cell lung cancer