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Table 1 Lymph node involvement and clinicopathological characteristics of all pT1 patients, n (%)

From: Association of lymph node involvement with the prognosis of pathological T1 invasive non-small cell lung cancer

Characteristics pN0 (n = 263) pN1 (n = 28) pN1+N2 (n = 19) pN2 (n=15) P value
Age (mean), yrs. 62 ± 9 61 ± 7 59 ± 9 58 ± 7  
 ≤60 101 (31.1) 12 (3.7) 7 (2.2) 10 (3.1) 0.185
 >60 162 (49.8) 16 (4.9) 12 (3.7) 5 (1.5)  
Gender
 Male 145 (44.6) 22 (6.8)a 14 (4.3) 6 (1.8) 0.020
 Female 118 (36.3) 6 (1.8) 5 (1.5) 9 (2.8)  
Tobacco smoking history
 Never 147 (45.2) 18 (5.5) 6 (1.8)b 9 (2.8) 0.044
 Ever/current 116 (35.7) 10 (3.1) 13 (4.0) 6 (1.8)  
CEA level (n = 395)
 <5.0 IU/mL 216 (66.5)c 16 (4.9) c 9 (2.8) 9 (2.8) <0.0001
 ≥5.0 IU/mL 47 (14.5) 12 (3.7) 10 (3.1) 6 (1.8)  
Tumor location
 Upper lobe 154 (47.4) 12 (3.7) 10 (3.1) 10 (3.1) 0.150
 Middle lobe 18 (5.5) 2 (0.6) 1 (0.3) 2 (0.6)  
 Lower lobe 87 (26.8) 12 (3.7) 6 (1.8) 2 (0.6)  
 Middle-lower lobe 4 (1.2) 2 (0.6) 2 (0.6) 1 (0.3)  
Type of surgery
 Lobectomy 235 (72.3) 23 (7.1) 17 (5.2) 13 (4.0) 0.720
 Limited resection 28 (8.6) 5 (1.5) 2 (0.6) 2 (0.6)  
Adjuvant chemotherapy
 No 166 (51.1)d 0d 0d 0d <0.0001
 Yes 97 (29.8) 28 (8.6) 19 (5.8) 15 (4.6)  
Tumor size, cm
 ≤1.0 28 (8.6)e 0e 0 0 0.021
 1.0–≤2.0 153 (47.1) 12 (3.7) 10 (3.1) 7 (2.2)  
 2.0–≤3.0 82 (25.2) 16 (4.9) 9 (2.8) 8 (2.5)  
Histology
 IAC 220 (67.7)f 12 (3.7)f 10 (3.1)f 11 (3.4)f <0.0001
 SCC 43 (13.2) 16 (4.9) 9 (2.8) 4 (1.2)  
  1. CEA carcinoembryonic antigen, IAC invasive lung adenocarcinoma, SCC squamous cell lung cancer
  2. aMale vs. female
  3. bnever smoked tobacco vs. ever/current
  4. cCEA level <5.0 IU/mL vs. ≥5.0 IU/mL
  5. dno adjuvant chemotherapy vs. adjuvant chemotherapy
  6. etumor size ≤1.0 vs. 1.0–≤2.0 vs. 2.0–≤3.0
  7. fIAC vs. SCC