Skip to main content

Table 2 Comparison of clinicopathologic factors according to tumor location in patients with adenocarcinoma of the EGJ and the upper third of the stomach

From: Mediastinal lymph node dissection and distal esophagectomy is not essential in early esophagogastric junction adenocarcinoma

Variables Tumor location P value
Siewert 2 Siewert 3 Upper third
Age in years, mean 63.1 (±11.5) 59.6 (±11.3) 56.5 (±11.7) <0.001
Sex     =0.232
 Male 71 (78.9%) 156 (73.9%) 261 (70.4%)  
 Female 19 (21.1%) 55 (26.1%) 110 (29.6%)  
Tumor size in cm 4.36 (±2.33) 4.74 (±2.36) 4.78 (±2.71) =0.365
Gross appearance     =0.001
 I 4 (4.4%) 3 (1.4%) 6 (1.6%)  
 IIa/IIb/IIc 26 (28.9%) 67 (31.8%) 169 (45.6%)  
 III 0 (0.0%) 2 (0.9%) 4 (1.1%)  
 B1 5 (5.6%) 8 (3.8%) 5 (1.3%)  
 B2/B3 55 (61.1%) 131 (62.1%) 187 (50.4%)  
Differentiation     =0.003
 Differentiated 49 (54.4%) 90 (42.7%) 131 (35.3%)  
 Undifferentiated 41 (45.6%) 121 (57.3%) 240 (64.7%)  
Lauren’s classificationa     =0.002
 Intestinal 60 (67.4%) 109 (51.7%) 164 (44.3%)  
 Diffuse 24 (27.0%) 77 (36.5%) 164 (44.3%)  
 Mixed 5 (5.6%) 25 (11.8%) 42 (11.4%)  
T stage     =0.001
 T1 30 (33.4%) 72 (34.1%) 175 (47.1%)  
 T2 18 (20.0%) 36 (17.1%) 46 (12.4%)  
 T3 25 (27.8%) 74 (35.1%) 102 (27.5%)  
 T4a 15 (16.7%) 24 (11.4%) 41 (11.1%)  
 T4b 2 (2.1%) 5 (2.3%) 7 (1.9%)  
No. of metastatic LNs 3.1 (±5.4) 2.1 (±3.9) 1.8 (±4.6) =0.064
No. of harvested LNs 27.6 (±10.7) 29.5 (±12.1) 30.7 (±12.3) =0.074
Stage     =0.015
 1 40 (44.4%) 95 (45.0%) 203 (54.7%)  
 2 21 (23.3%) 58 (27.5%) 100 (27.0%)  
 3 29 (32.3%) 58 (27.5%) 68 (18.3%)  
Proximal margin, cm 0.75 (±0.66) 1.36 (±0.79) 3.41 (±1.95) <0.001
Lymphovascular invasiona     =0.219
 Present 34 (37.8%) 67 (31.9%) 106 (28.6%)  
 Not identified 56 (62.2%) 143 (68.1%) 265 (71.4%)  
Perineural invasiona     =0.748
 Present 26 (29.9%) 53 (26.5%) 96 (25.9%)  
 Not identified 61 (70.1%) 147 (73.5%) 275 (74.1%)  
  1. aThese variables were missing from the pathology reports of some of the patients