Table 2 Comparison of clinicopathologic factors according to tumor location in patients with adenocarcinoma of the EGJ and the upper third of the stomach

Age in years, mean

63.1 (±11.5)

59.6 (±11.3)

56.5 (±11.7)

<0.001

Sex

=0.232

 Male

71 (78.9%)

156 (73.9%)

261 (70.4%)

 Female

19 (21.1%)

55 (26.1%)

110 (29.6%)

Tumor size in cm

4.36 (±2.33)

4.74 (±2.36)

4.78 (±2.71)

=0.365

Gross appearance

=0.001

 I

4 (4.4%)

3 (1.4%)

6 (1.6%)

 IIa/IIb/IIc

26 (28.9%)

67 (31.8%)

169 (45.6%)

 III

0 (0.0%)

2 (0.9%)

4 (1.1%)

 B1

5 (5.6%)

8 (3.8%)

5 (1.3%)

 B2/B3

55 (61.1%)

131 (62.1%)

187 (50.4%)

Differentiation

=0.003

 Differentiated

49 (54.4%)

90 (42.7%)

131 (35.3%)

 Undifferentiated

41 (45.6%)

121 (57.3%)

240 (64.7%)

Lauren’s classification^a

=0.002

 Intestinal

60 (67.4%)

109 (51.7%)

164 (44.3%)

 Diffuse

24 (27.0%)

77 (36.5%)

164 (44.3%)

 Mixed

5 (5.6%)

25 (11.8%)

42 (11.4%)

T stage

=0.001

 T1

30 (33.4%)

72 (34.1%)

175 (47.1%)

 T2

18 (20.0%)

36 (17.1%)

46 (12.4%)

 T3

25 (27.8%)

74 (35.1%)

102 (27.5%)

 T4a

15 (16.7%)

24 (11.4%)

41 (11.1%)

 T4b

2 (2.1%)

5 (2.3%)

7 (1.9%)

No. of metastatic LNs

3.1 (±5.4)

2.1 (±3.9)

1.8 (±4.6)

=0.064

No. of harvested LNs

27.6 (±10.7)

29.5 (±12.1)

30.7 (±12.3)

=0.074

Stage

=0.015

 1

40 (44.4%)

95 (45.0%)

203 (54.7%)

 2

21 (23.3%)

58 (27.5%)

100 (27.0%)

 3

29 (32.3%)

58 (27.5%)

68 (18.3%)

Proximal margin, cm

0.75 (±0.66)

1.36 (±0.79)

3.41 (±1.95)

<0.001

Lymphovascular invasion^a

=0.219

 Present

34 (37.8%)

67 (31.9%)

106 (28.6%)

 Not identified

56 (62.2%)

143 (68.1%)

265 (71.4%)

Perineural invasion^a

=0.748

 Present

26 (29.9%)

53 (26.5%)

96 (25.9%)

 Not identified

61 (70.1%)

147 (73.5%)

275 (74.1%)