Table 3 Univariate analyses of recurrence-free survival depending on treatment characteristics
N | Estimated 1-year RFS (95% CI) | Estimated 2-year RFS (95% CI) | Estimated 5-year RFS (95% CI) | P (log-rank)* | |
|---|---|---|---|---|---|
Margin status after initial resection | |||||
R0 | 13 | 83.1 (47.2–95.5) | 63.3 (28.6–84.6) | 63.3 (28.6–84.6) | |
R1/2 | 55 | 91.9 (79.8–96.9) | 91.9 (79.8–96.9) | 87.1 (73.3–94.0) | 0.053 |
Re-excision | |||||
No | 13 | 82.1 (44.4–95.3) | 59.8 (24.1–83.1) | 47.9 (15.5–74.7) | |
Yes | 55 | 92.0 (80.1–96.9) | 92.0 (80.1–96.9) | 89.6 (76.7–95.6) | 0.002 |
Margin status after first treatment round (initial resection + re-excision) | |||||
R0 | 65 | 89.9 (78.8–95.3) | 86.0 (73.9–92.8) | 84.0 (71.3–91.4) | |
R1 | 3 | 100 (−) | 100 (−) | (−) | – |
Wound closure during first treatment round | |||||
Primary closure | 35 | 80.8 (62.1–90.9) | 73.6 (53.8–85.9) | 69.7 (49.6–83.1) | |
Non-primary closure (plastic surgical tissue transfer) | 32 | 100 (−) | 100 (−) | 96.2 (75.7–99.4) | 0.006 |
Adjuvant radiotherapy | |||||
No | 65 | 89.9 (78.8–95.3) | 86.0 (73.9–92.8) | 82.0 (69.0–89.9) | |
Yes | 3 | 100 (−) | 100 (−) | 100 (−) | – |
Distance of closest negative margin (R0 group) in cm | |||||
≤0.2 | 11 | 81.8 (44.7–95.1) | 71.6 (35.0–89.9) | 71.6 (35.0–89.9) | |
0.2–0.5 | 11 | 88.9 (43.3–98.4) | 71.1 (23.3–92.3) | 71.1 (23.3–92.3) | |
0.5–1.0 | 10 | 77.8 (36.5–93.9) | 77.8 (36.5–93.9) | 77.8 (36.5–93.9) | |
>1.0 | 16 | 100 (−) | 100 (−) | 100 (−) | 0.039** |