Table 7 Adverse events in patients treated as second-or-greater line setting (n = 102)
Adverse event | G0 | G1 | G2 | G3 | G4 | NE | All grades (%) | Grade 3/4 (%) |
|---|---|---|---|---|---|---|---|---|
Leucocyte | 6 | 5 | 13 | 34 | 42 | 2 | 92.2 | 74.5 |
Neutrophils | 7 | 4 | 12 | 22 | 54 | 3 | 90.2 | 74.5 |
Hemoglobin | 17 | 33 | 30 | 18 | 2 | 2 | 81.4 | 19.6 |
Platelets | 36 | 18 | 12 | 21 | 13 | 2 | 62.7 | 33.3 |
AST | 65 | 32 | 1 | 2 | 0 | 2 | 34.3 | 2.0 |
ALT | 60 | 30 | 8 | 2 | 0 | 2 | 39.2 | 2.0 |
Anorexia | 39 | 45 | 10 | 2 | 0 | 6 | 55.9 | 2.0 |
Nausea | 48 | 38 | 10 | 1 | 0 | 5 | 48.0 | 1.0 |
Vomiting | 77 | 17 | 3 | 0 | 0 | 5 | 19.6 | 0.0 |
Diarrhea | 86 | 9 | 1 | 1 | 0 | 5 | 10.8 | 1.0 |
Fatigue | 36 | 47 | 10 | 5 | 0 | 4 | 60.8 | 4.9 |
Febrile neutropenia | 91 | 0 | 0 | 10 | 0 | 1 | 9.8 | 9.8 |
Fever | 73 | 16 | 11 | 0 | 0 | 2 | 26.5 | 0.0 |
Infection | 89 | 4 | 4 | 3 | 1 | 1 | 11.8 | 3.9 |
Dyspnea | 93 | 4 | 1 | 3 | 0 | 1 | 7.8 | 2.9 |
Interstitial pneumonia | 94 | 2 | 1 | 4 | 0 | 1 | 6.9 | 3.9 |
Neuropathy | 96 | 0 | 5 | 0 | 0 | 1 | 4.9 | 0.0 |
Rash | 90 | 2 | 5 | 4 | 0 | 1 | 10.8 | 3.9 |
Edema | 101 | 0 | 1 | 0 | 0 | 0 | 1.0 | 0.0 |
Mucositis | 99 | 1 | 2 | 0 | 0 | 0 | 2.9 | 0.0 |
Allergic reaction | 100 | 0 | 2 | 0 | 0 | 0 | 2.0 | 0.0 |