Table 5 Subgroup analysis stratified by smoke status
From: Associations of DNMT3B −149C>T and −2437T>A polymorphisms and lung cancer risk in Chinese population
Genotype | No. of cases (%) | No. of controls (%) | ORa (95% CI) | P value |
|---|---|---|---|---|
−149C>T | ||||
Smokers | ||||
TT | 23 (5.1) | 15 (5.6) | 0.81 (0.84 2.35) | 0.571 |
CT | 135 (29.4) | 95 (35.5) | 0.74 (0.45 1.83) | 0.469 |
CC | 300 (65.5) | 158 (58.9) | Reference | |
CT+TT | 158 (34.5) | 110 (41.1) | 0.76 (0.52 1.17) | 0.274 |
Non-smokers | ||||
TT | 19 (8.5) | 16 (4.9) | 1.59 (0.37 1.94) | 0.371 |
CT | 62 (27.4) | 124 (37.1) | 0.69 (0.24 1.64) | 0.108 |
CC | 145 (64.1) | 194 (58.0) | Reference | |
CT+TT | 81 (35.9) | 140 (42) | 0.77 (0.49 1.25) | 0.251 |
−2437T>A | ||||
Smokers | ||||
AA | 47 (51.9) | 31 (51.6) | 1.53 (0.42 1.97) | 0.473 |
TA | 173 (37.8) | 98 (36.7) | 1.78 (0.35 1.67) | 0.082 |
TT | 138 (10.2) | 139 (11.7) | Reference | |
TA+AA | 220 (89.7) | 129 (88.3) | 1.72 (0.68 1.49) | 0.627 |
Non-smokers | ||||
AA | 35 (47.9) | 29 (47.8) | 0.71 (0.34 1.68) | 0.376 |
TA | 204 (44.4) | 111 (41.5) | 1.07 (0.32 1.85) | 0.723 |
TT | 219 (7.7) | 128 (10.7) | Reference | |
TA+AA | 239 (92.3) | 140 (89.3) | 1.00 (0.64 1.59) | 0.504 |