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Table 3 Subgroup analysis stratified by pathological type

From: Associations of DNMT3B −149C>T and −2437T>A polymorphisms and lung cancer risk in Chinese population

Genotype Pathological type
  SCC ORa (95%CI) AC ORa (95%CI) ASC ORa (95%CI) SCLC ORa (95%CI)
−149C>T
TT 19 (8.5) 0.54 (0.31 1.56) 15 (5.8) 0.23 (0.33 2.01) 6 (9.8) 0.17 (0.54 1.98) 7 (4.8) 0.24 (0.31 2.12)
CT 63 (28.7) 0.76 (0.25 1.81) 81 (31.7) 0.81 (0.77 1.67) 22 (34.1) 0.42 (0.34 1.63) 37 (25.8) 0.58 (0.22 1.37)
CC 139 (62.8) Reference 161 (62.5) Reference 36 (56.1) Reference 99 (69.4) Reference
CT+TT 82 (37.2) 0.82 (0.53 1.27) 96 (37.5) 0.90 (0.59 1.39) 68 (.43.9) 0.55 (0.26 1.15) 44 (30.6) 0.63 (0.35 1.44)
−2437T>A
AA 31 (14.0) 0.57 (1.21 2.14) 11 (4.2) 0.45 (0.72 1.51) 6 (9.8) 0.26 (1.32 2.31) 14 (9.7) 0.37 (0.87 1.92)
TA 79 (35.6) 0.85 (0.58 1.67) 122 (47.5) 0.89 (0.22 1.21) 22 (34.1) 0.76 (0.28 1.64) 55 (38.7) 0.88 (0.64 1.55)
TT 111 (50.4) Reference 124 (48.3) Reference 36 (56.1) Reference 73 (51.6) Reference
TA+AA 110 (49.6) 0.99 (0.65 1.52) 133 (51.7) 1.08 (0.71 1.64) 68 (43.9) 0.83 (0.43 1.61) 69 (48.4) 0.95 (0.56 1.64)
  1. SCC squamous cell carcinoma, AC adenomatous carcinoma, ASC adenosquamous carcinomas, SCLC small cell lung cancer, TNM tumor-node-metastasis, OR odds ratio, CI confidence interval
  2. aAdjusted for age and sex in a logistic regression model