Table 3 Subgroup analysis stratified by pathological type
From: Associations of DNMT3B −149C>T and −2437T>A polymorphisms and lung cancer risk in Chinese population
Genotype | Pathological type | |||||||
|---|---|---|---|---|---|---|---|---|
SCC | ORa (95%CI) | AC | ORa (95%CI) | ASC | ORa (95%CI) | SCLC | ORa (95%CI) | |
−149C>T | ||||||||
TT | 19 (8.5) | 0.54 (0.31 1.56) | 15 (5.8) | 0.23 (0.33 2.01) | 6 (9.8) | 0.17 (0.54 1.98) | 7 (4.8) | 0.24 (0.31 2.12) |
CT | 63 (28.7) | 0.76 (0.25 1.81) | 81 (31.7) | 0.81 (0.77 1.67) | 22 (34.1) | 0.42 (0.34 1.63) | 37 (25.8) | 0.58 (0.22 1.37) |
CC | 139 (62.8) | Reference | 161 (62.5) | Reference | 36 (56.1) | Reference | 99 (69.4) | Reference |
CT+TT | 82 (37.2) | 0.82 (0.53 1.27) | 96 (37.5) | 0.90 (0.59 1.39) | 68 (.43.9) | 0.55 (0.26 1.15) | 44 (30.6) | 0.63 (0.35 1.44) |
−2437T>A | ||||||||
AA | 31 (14.0) | 0.57 (1.21 2.14) | 11 (4.2) | 0.45 (0.72 1.51) | 6 (9.8) | 0.26 (1.32 2.31) | 14 (9.7) | 0.37 (0.87 1.92) |
TA | 79 (35.6) | 0.85 (0.58 1.67) | 122 (47.5) | 0.89 (0.22 1.21) | 22 (34.1) | 0.76 (0.28 1.64) | 55 (38.7) | 0.88 (0.64 1.55) |
TT | 111 (50.4) | Reference | 124 (48.3) | Reference | 36 (56.1) | Reference | 73 (51.6) | Reference |
TA+AA | 110 (49.6) | 0.99 (0.65 1.52) | 133 (51.7) | 1.08 (0.71 1.64) | 68 (43.9) | 0.83 (0.43 1.61) | 69 (48.4) | 0.95 (0.56 1.64) |