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Table 1 The profiles of eligible studies

From: The prognostic value of MGMT promoter status by pyrosequencing assay for glioblastoma patients’ survival: a meta-analysis

Publication year Study Country Age of patient
Mean (range or standard derivation)
Cut-off value by PSQ CpGs Sample source No. patientsa Disease status Treatment experience Score in NOS
2015 Dae Cheol Kim Korea 51.4 (26.4–87.2) 9 % 5 CpGs FFPE 104 Newly diagnosed GMB No all patients treated with TMZ 5
2015 Robert W. Rapkinsb Australia 58.3 (25.0–85.0) 9 % 5 CpGs FFPE 303 Newly diagnosed GMB Surgery + radiotherapy + TMZ+ adjuvant TMZ 6
2015 Robert W. Rapkinsb Australia 57.8 (22.3–84.3) 9 % 5 CpGs FFPE 303 Newly diagnosed GMB Surgery + radiotherapy + TMZ+ adjuvant TMZ 5
2014 Veronique Quillien France 58 (21.0–73.0) 9 % 16 CpGs FFPE 89 Newly diagnosed GMB Stupp protocol 5
2014 Vincent Peter Collins UK 53 (41–60) 10 % 16 CpGs FFPE 275 Recurrent high-grade GMB PCV OR two TMZ schedules 5
2014 Dong Shen China 56 (35–71) 10 % 12 CpGs FFPE 128 Recurrent high-grade GMB Surgery + radiotherapy + TMZ+ adjuvant TMZ 5
2012 Guido Reifenberge Germany 74.1 (70.0–86.6) 8 % 5 CpGs Frozen sample 85 Newly diagnosed GMB Treated with alkylating agents 5
2012 Veronique Quillien France 57.5 (21.0–73.0) 8 % 5 CpGs FFPE and frozen sample 99 Newly diagnosed GMB Standard care treatment 5
2011 Miyuki Uno Brazil 50.2 (14.6) 10 % 5 CpGs Frozen sample 29 Newly diagnosed GMB Adjuvant radiotherapy and/or chemotherapy (carmustine) 5
2011 Shani Mulholland Sweden NA 10 % 16 CpGs Frozen sample 362 GMB Surgery + adjuvant treatment (no TMZ) 5
2009 J Dunn UK 55 (18–68) 10 % 12 CpGs FFPE or frozen sample 108 Newly diagnosed GMB Surgery + radiotherapy + TMZ+ adjuvant TMZ 5
  1. Abbreviations: FFPE formalin-fixed paraffin-embedded, PCV chemotherapy procotol: procarbazine, CCNU, and vincristine
  2. aThe number of patients whose methylation status of MGMT promoter was measured successfully by PSQ
  3. bThis publication included two independently studies, Australian cohort (AGOG) and American cohort (UCLA)