Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel improves survival for patients with peritoneal carcinomatosis from abdominal and pelvic malignancies

Table 5 Detailed information on 16 cases with SAE

Events	Gender/age (year)	Primary tumor	PC time	PCI	Resection		No. Anastomosis	CC	SAEs	Intervention^c	OS (month)
Events	Gender/age (year)	Primary tumor	PC time	PCI	Organ	Peritoneal	No. Anastomosis	CC	SAEs	Intervention^c	OS (month)
Intestinal obstruction (n = 5, 4.8 %)	F/45	Colon	Met	24	2	9	1	1	CIO/AI	CT	64.5, D
	M/40	Colon	Met	23	0	3	0	2	IIO/AI	CT	12.2, D
	F/23	Stomach	Syn	30	1	2	2	2	CIO/AI	CT	2.3, D
	F/52	Colon	Syn	15	0	8	0	1	IIO/AI	CT	58.8, S
	F/31	Colon	Met	24	5	9	1	1	CIO/AI and combined gastroplegia	CT	21.2, D
Intestinal leakage (n = 4, 3.8 %)	F/26	Colon	Syn	33	2	3	1	3	Limited peritonitis syndrome	CT	12.6, D
	F/40^a	Stomach	Syn	28	5	9	3	2	Staphylococcus aureus and fungus infection, generalized peritonitis, abdominal abscess	CT	5.5, D
	M/24^a	Colon	Syn	16	7	1	1	1	Generalized peritonitis syndrome	CT	6.3, D
	F/53	Ovary	Syn	39	4	9	1	1	Generalized peritonitis syndrome	reoperation	31.8, D
Septicemia (n = 4, 3.8 %)	F/41	Stomach	Met	18	0	5	0	2	Candida parapsilosis	CT	14.1, S
	F/40^b	Stomach	Syn	28	5	9	3	2	Staphylococcus aureus and Candida tropicalis septicemia	CT	5.5, D
	M/24^b	Colon	Syn	16	7	1	1	1	Gram-negative bacilli	CT	6.3, D
	M/64	Pseudomyxoma peritonei	Syn	33	5	10	1	2	Enterococcus faecium infection	CT	7.0, S
Diarrhea (n = 2, 1.9 %)	F/62	Colon	Met	25	6	7	2	3	Over 8 stools per day	CT	6.0, D
Diarrhea (n = 2, 1.9 %)	F/64	Colon	Met	24	3	6	2	3	Over 8 stools per day	CT	11.1, D
Acute myocardium infarction (n = 1, 0.9 %)	F/73	Colon	Syn	26	6	9	2	1	Grades 5	CT	25.9, D

Common Terminology Criteria for Adverse Events version 4.0
^aTwo patients died of SAE
^bDifferent SAEs developed in the same patient
^cAll patients recovered after intervention
M male, F female, Syn synchronous, Met metachronous, CIO complete intestinal obstruction, IIO incomplete intestinal obstruction, AI adynamic ileus, CT conservative treatment, D death, S survival

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