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Table 5 Detailed information on 16 cases with SAE

From: Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel improves survival for patients with peritoneal carcinomatosis from abdominal and pelvic malignancies

Events Gender/age (year) Primary tumor PC time PCI Resection No. Anastomosis CC SAEs Interventionc OS (month)
Organ Peritoneal
Intestinal obstruction (n = 5, 4.8 %) F/45 Colon Met 24 2 9 1 1 CIO/AI CT 64.5, D
M/40 Colon Met 23 0 3 0 2 IIO/AI CT 12.2, D
F/23 Stomach Syn 30 1 2 2 2 CIO/AI CT 2.3, D
F/52 Colon Syn 15 0 8 0 1 IIO/AI CT 58.8, S
F/31 Colon Met 24 5 9 1 1 CIO/AI and combined gastroplegia CT 21.2, D
Intestinal leakage (n = 4, 3.8 %) F/26 Colon Syn 33 2 3 1 3 Limited peritonitis syndrome CT 12.6, D
F/40a Stomach Syn 28 5 9 3 2 Staphylococcus aureus and fungus infection, generalized peritonitis, abdominal abscess CT 5.5, D
M/24a Colon Syn 16 7 1 1 1 Generalized peritonitis syndrome CT 6.3, D
F/53 Ovary Syn 39 4 9 1 1 Generalized peritonitis syndrome reoperation 31.8, D
Septicemia (n = 4, 3.8 %) F/41 Stomach Met 18 0 5 0 2 Candida parapsilosis CT 14.1, S
F/40b Stomach Syn 28 5 9 3 2 Staphylococcus aureus and Candida tropicalis septicemia CT 5.5, D
M/24b Colon Syn 16 7 1 1 1 Gram-negative bacilli CT 6.3, D
M/64 Pseudomyxoma peritonei Syn 33 5 10 1 2 Enterococcus faecium infection CT 7.0, S
Diarrhea (n = 2, 1.9 %) F/62 Colon Met 25 6 7 2 3 Over 8 stools per day CT 6.0, D
F/64 Colon Met 24 3 6 2 3 Over 8 stools per day CT 11.1, D
Acute myocardium infarction (n = 1, 0.9 %) F/73 Colon Syn 26 6 9 2 1 Grades 5 CT 25.9, D
  1. Common Terminology Criteria for Adverse Events version 4.0
  2. aTwo patients died of SAE
  3. bDifferent SAEs developed in the same patient
  4. cAll patients recovered after intervention
  5. M male, F female, Syn synchronous, Met metachronous, CIO complete intestinal obstruction, IIO incomplete intestinal obstruction, AI adynamic ileus, CT conservative treatment, D death, S survival