Association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility: a meta-analysis based on 38 case-control studies with 40,985 subjects

Table 3 Results of subgroup analyses of MTHFR gene 1298A>C polymorphism

Stratified by	Comparison	Number of datasets	Dominant genetic model		Allele contrast
Stratified by	Comparison	Number of datasets	OR (95 % CI)	P value	OR (95 % CI)	P value
Ethnicity	Asian	15	1.00 (0.99–1.00)	0.506	1.01 (0.99–1.02)	0.249
	Caucasian	13	0.98 (0.95–1.01)	0.129	0.97 (0.93–1.00)	0.059
	Mixed	10	0.99 (0.99–1.00)	0.852	0.99 (0.98–1.01)	0.660
Source of control	PB	21	1.00 (0.99–1.01)	0.931	1.00 (0.99–1.02)	0.830
	HB	15	0.98 (0.96–1.00)	0.037	0.97 (0.94–1.00)	0.092
	NA	2	0.99 (0.94–1.04)	0.793	0.99 (0.91–1.08)	0.892
Deviation from HWE	Yes	8	0.98 (0.95–1.00)	0.019	0.98 (0.95–1.01)	0.102
Deviation from HWE	No	30	1.00 (0.99–1.01)	0.909	1.00 (0.98–1.01)	0.801

ISSN: 1477-7819