Association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility: a meta-analysis based on 38 case-control studies with 40,985 subjects

Table 2 Summary of different genetic model comparison results of MTHFR gene 1298A>C polymorphism

Genetic model	OR (95 % CI)	Z	P value	I ² %	P _het	Effect model	Egger’s test
Genetic model	OR (95 % CI)	Z	P value	I ² %	P _het	Effect model	t value	P value
AA + AC vs. CC	0.99 (0.99–1.00)	1.23	0.218	50.5	0.000	R	−2.72	0.010
AA vs. AC + CC	1.00 (0.97–1.02)	0.15	0.880	35.9	0.016	R	−1.45	0.155
AA vs. CC	0.99 (0.98–1.01)	0.86	0.390	43.8	0.002	R	−2.75	0.014
AC vs. CC	0.99 (0.97–1.00)	1.48	0.138	41.2	0.005	R	−2.55	0.015
A vs. C	0.99 (0.98–1.01)	0.92	0.360	55.5	0.000	R	−2.27	0.029

OR odds ratio, CI confidence interval, R random-effect model, P _het P value for heterogeneity
P < 0.05 stands for statistical significance

ISSN: 1477-7819