Skip to main content

Table 1 The main characteristics of studies included in this meta-analysis and the distribution of MTHFR gene 1298A>C genotypes and alleles among cases and controls

From: Association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility: a meta-analysis based on 38 case-control studies with 40,985 subjects

First author

Year

Ethnicity

Source of controls

Cases

Controls

Cases

Controls

Deviation from HWE

Quality grade

AA

AC

CC

AA

AC

CC

A

C

A

C

Aram

2012

Caucasian

HB

35

55

20

30

75

5

125

95

135

85

Yes

+

Awwad

2015

Asian

PB

68

61

17

58

64

13

197

95

180

90

No

++

Carvalho Barbosa Rde

2012

Mixed

PB

68

80

17

72

84

9

216

114

228

102

Yes

+

Chen

2005

Mixed

PB

558

417

87

536

457

110

1533

591

1529

677

No

++

Cheng

2008

Asian

HB

207

125

19

310

207

17

539

163

827

241

Yes

+

Chou

2006

Asian

HB

104

30

8

172

95

18

238

46

439

131

No

+

Ergul

2003

Caucasian

HB

50

48

20

90

85

18

148

88

265

121

No

+

Ericson

2009

Caucasian

PB

242

242

57

487

480

105

726

356

1454

690

No

++

Forsti

2004

Caucasian

NA

94

102

27

133

127

38

290

156

393

203

No

+

Gao

2009

Asian

PB

446

165

9

425

188

11

1057

183

1038

210

No

++

He

2014

Asian

HB

138

132

40

173

155

53

408

212

501

261

No

+

Hosseini

2011

Caucasian

HB

36

96

162

60

135

105

168

420

255

345

No

+

Inoue

2008

Asian

PB

225

139

16

387

234

41

589

171

1008

316

No

++

Justenhoven

2005

Caucasian

PB

273

256

53

295

266

73

802

362

856

412

No

++

Kakkoura

2015

Mixed

PB

138

465

468

150

500

484

741

1401

800

1468

No

++

Kotsopoulos

2008

Caucasian

HB

466

390

85

398

309

73

1322

560

1105

455

No

+

Lajin

2012

Caucasian

HB

44

52

23

65

48

13

140

98

178

74

No

+

Le Marchand

2004

Mixed

PB

741

372

77

1493

801

120

1854

526

3787

1041

No

++

Lissowska

2007

Caucasian

PB

892

874

220

1086

941

251

2658

1314

3113

1443

Yes

+

Liu

2013

Asian

HB

206

176

53

214

172

49

588

282

600

270

No

+

Lopez-Cortes

2015

Mix

PB

110

3

1

191

3

1

223

5

385

5

Yes

+

Lu

2015

Asian

HB

369

172

19

352

185

23

910

210

889

231

No

+

Ma

2009

Mixed

HB

269

168

21

279

157

22

706

210

715

201

No

+

Mir

2008

Asian

NA

15

19

1

11

22

0

49

21

44

22

Yes

+

Ozen

2013

Mix

PB

17

29

5

71

35

0

63

39

177

35

Yes

+

Papandreou

2012

Caucasian

HB

129

135

36

136

116

31

393

207

388

178

No

+

Platek

2009

Mix

PB

443

402

83

842

758

181

1288

568

2442

1120

No

++

Qi

2004

Asian

PB

155

58

4

144

71

3

368

66

359

77

No

++

Sangrajrang

2010

Asian

HB

302

223

38

258

206

23

827

299

722

252

Yes

+

Sharp

2002

Caucasian

PB

27

25

3

24

25

11

79

31

73

47

No

++

Shrubsole

2004

Asian

PB

768

311

42

824

344

40

1847

395

1992

424

No

++

Stevens

2007

Mixed

PB

224

228

42

252

201

40

676

312

705

281

No

++

Vainer

2010

Caucasian

HB

398

353

80

379

330

76

1149

513

1088

482

No

+

Weiwei

2014

Asian

HB

135

129

32

151

130

25

399

193

432

180

No

+

Wu

2012

Asian

PB

37

32

6

42

28

5

106

44

112

38

No

++

Xu

2007

Mixed

PB

558

417

87

536

457

110

1533

591

1529

677

No

++

Zhang

2015

Asian

PB

98

87

31

105

84

27

283

149

294

138

No

++

Ziva Cerne

2011

Caucasian

PB

258

219

47

131

117

21

735

313

379

159

No

++

  1. PB population-based study, HB hospital-based study, NA not available, HWE Hardy-Weinberg equilibrium