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Table 1 Immunostaining for cytoplasmic p62, nuclear Beclin-1 and LC3 expression

From: Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status

 

Cytoplasmic p62 expression

Nuclear Beclin-1 expression

LC3 expression

 

Negative

Positive

p value

Negative

Positive

p value

Negative

Positive

p value

Histological grading

  

0.920

  

0.746

  

0.016

 1

3 (10 %)

27 (90 %)

 

15 (53.6 %)

13 (46.4 %)

 

25 (83.3 %)

5 (16.7 %)

 

 2

9 (12.6 %)

61 (87.1 %)

 

37 (53.6 %)

32 (46.4 %)

 

50 (74.6 %)

17 (25.4 %)

 

 3

3 (11.5 %)

23 (88.5 %)

 

12 (63.2 %)

7 (36.8 %)

 

13 (50 %)

13 (50 %)

 

Tumour stage

  

0.491

  

0.373

  

0.124

 pT1

0 (0 %)

3 (100 %)

 

1 (33.3 %)

2 (66.6 %)

 

2 (66.7 %)

1 (33.3 %)

 

 pT2

0 (0 %)

12 (100 %)

 

4 (36.4 %)

7 (63.6 %)

 

10 (83.3 %)

2 (16.7 %)

 

 pT3

11 (14.3 %)

66 (85.7 %)

 

43 (60.6 %)

28 (48.3 %)

 

57 (76 %)

18 (24 %)

 

 pT4

4 (12.5 %)

28 (87.5 %)

 

15 (51.7 %)

14 (48.3 %)

 

17 (54.8 %)

14 (45.2 %)

 

Lymph node metastases status

  

0.072

  

0.500

  

0.272

 pN0

4 (6.9 %)

54 (93.1 %)

 

31 (55.4 %)

25 (44.6 %)

 

42 (75 %)

14 (25 %)

 

 pN+

11 (17.2 %)

53 (82.8 %)

 

30 (53.6 %)

26 (46.4 %)

 

43 (68.3 %)

20 (31.7 %)

 

Distant metastasis

  

0.189

  

0.118

  

0.027

 pM0

9 (9.6 %)

85 (90.4 %)

 

52 (57.8 %)

38 (42.2 %)

 

71 (77.2 %)

21 (22.8 %)

 

 pM+

5 (17.9 %)

23 (82.1 %)

 

9 (40.9 %)

12 (59.1 %)

 

15 (55.6 %)

12 (44.4 %)

 

KRAS status

  

0.607

  

0.297

  

0.242

 KRAS wildtype

11 (12.2 %)

79 (87.8 %)

 

46 (57.5 %)

34 (42.5 %)

 

66 (74.2 %)

23 (25.8 %)

 

 KRAS mutated

4 (11.8 %)

30 (88.2 %)

 

17 (50 %)

17 (50 %)

 

21 (65.6 %)

11 (34.4 %)

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