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Table 2 Summary of the studies reporting on non-solitary (or not specified) splenic metastases from NPC

From: Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature

Year

First author

Type of study

Number and type of patients considered

Patients with splenic metastases from NPC

Methods of detection

Surgery performed

Confirmatory histology of NPC splenic metastases

Relapse and survival rates

1952

Abrams et al. [5]

CS

1000 patients with splenic metastases from carcinomas

3 (0.3 %)

Autopsy

NS

NS

NS

1989

Siniluoto et al. [37]

CS

31 patients with splenic metastases

1 (3.2 %)

US

NS

NS

NS

2000

Wan et al. [39]

CS

53 patients with focal splenic lesions

2 (3.7 %)

US

NS

NS

NS

2000

Lam & Tang [3]

CS

92 patients with splenic metastases

4 (4.3 %)

NS

NS

UCNT

NS

2001

Gacani et al. [30]

CS

65 patients with NPC and DM

1 (1.5 %)

US

NS

NS

DM within 24 months after therapy

2004

Cho et al. [29]

CS

31 patients with recurrent type 2 NPC

1 (3.2 %)

NS

NS

NS

NS

2010

Radhakrishnan et al. [36]

CR

1 pediatric patient with UCNT

1

FDG-PET/CT

NS

NS

Death after 90 days of chemotherapy

2010

Ng et al. [35]

CS

179 NPC patients at high risk of residual disease or with suspected recurrence

1 (0.5 %)

WB-MRI and FDG-PET/CT

NS

NS

NS

2011

Gatenby et al. [31]

CS

21 patients undergone splenectomies for DM

1 (4.7 %)

NS

Primary tumor, radical neck dissection and synchronous splenectomy

SCC

DFS: 1 year 10 month

OS: 2 years 3 months

2013

Hsieh et al. [32]

CS

22 patients with non-keratinizing or undifferentiated NPC

1 (4.6 %)

US, CT or MRI

NS

NS

Median time to PD: 10 months;

Median OS: 16 months

2015

Mak et al. [34]

CS

558 patients with NPC

1 (0.2 %)

CT and PET/CT

NS

NS

10.8–18.4 months before DF;

Mean DSS in patients with DM: 31.2 months (95 % CI 20.9–41.6)

Mean OS in patients with DM: 28.2 months (95 % CI 19.3–37.1)

2015

Ma et al. [33]

CS

2 pediatric patients with NPC

1

FDG-PET/CT

NS

NS

NS

2015

Al Tamimi et al. [28]

CS

352 patients with NPC and DM

4 (1.1 %)

FDG-PET/CT

NS

NS

NS

  1. CR case report, CS case series, NPC nasopharyngeal carcinoma, UCNT undifferentiated carcinoma of the nasopharyngeal type, SCC squamous cell carcinoma, DM distant metastases, NS not specified, CT computed tomography, MRI magnetic resonance imaging, PET positron emission tomography, US ultrasounds, FNA fine-needle aspiration, DF distant failure, DFS disease-free survival, DSS disease-specific survival, OS overall survival, PD progressive disease