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Table 4 Factors associated with overall survival and disease-free survival on multivariate analyses for the entire patient population

From: Prognostic factors after pulmonary metastasectomy of colorectal cancers: influence of liver metastasis

Variable

Overall survival

Disease-free survival

HR

95 % CI

P value

HR

95 % CI

P value

Age at PM

1.03

1.01–1.04

0.001

CRC pTstage

1.65

1.23–2.2

0.001

1.22

1.0–1.48

0.05

CRC pNstage

1.32

1.08–1.61

0.006

1.19

1.03–1.38

0.021

Previous HM

1.79

1.22–2.63

0.003

1.45

1.1–1.92

0.008

DFI (≥12months)a

0.68

0.47–0.94

0.02

0.63

0.49–0.81

<0.001

Multiple LM

2.28

1.6–3.24

<0.001

1.66

1.27–2.16

<0.001

Size of largest LMb

1.06

0.94–1.19

0.343

1.1

1.0–1.2

0.043

Non-anatomical PMc

0.63

0.45–0.89

0.009

VATS

0.82

0.6–1.14

0.24

0.67

0.53–0.85

0.001

Adjuvant CTx

0.58

0.42–0.82

0.002

  1. HR hazard ratio, CI confidence interval, PM pulmonary metastasectomy, CRC colorectal cancer, HM hepatic metastasectomy, pTstage pathologic T stage, pNstage pathologic N stage, DFI disease-free interval, LM lung metastases, VATS video-assisted thoracoscopic surgery, CTx chemotherapy
  2. aDisease-free interval was calculated as the interval between the date of colorectal cancer resection and the date of pulmonary metastasectomy
  3. bThe long-axis diameter of the largest lung metastatic nodule was measured
  4. cNon-anatomical pulmonary resection included precision excision of metastatic nodules or wedge resection